http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2387326-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-267 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2007-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e21e9f7fda2952b3f58b522f345e75c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e139d5ccbbdcec006a71a9dd182f1a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37f7564c7f42b670bb575ede24c2e715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a09045ead19531017ee8e95eaae43ac |
| publicationDate | 2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2387326-T3 |
| titleOfInvention | 11-beta-hydroxysteroid dehydrogenase enzyme inhibitors Type 1 |
| abstract | A compound of formula (I) or a pharmaceutically acceptable salt thereof, or a combination thereof, where: n is 1; R1 is one of which is unsubstituted or substituted independently with 1 or 2 substituents independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, -CN, -NO2, -ORb, -SRb, -S (O) Rz, -S (O) 2Rz, -NRaRb, -C (O) Rb, -C (O) ORb, -C (O) NRaRb, -S (O) 2NRaRb, -C (> = NOH) NH2, -C (> = NH) NH2, -Rc, - (CRdRe) m-CN, - (CRdRe) m-ORb, - (CRdRe) m-SRb, - (CRdRe) mS (O) 2Rz, - (CRdRe) m-NRaRb, - (CRdRe) mC (O) Rb, - (CRdRe) mC ( O) ORb, - (CRdRe) mS (O) 2NRaRb, - (CRdRe) m-Rc, -N (Ra) - (CRdRe) mC (O) Rb, N (Ra) - (CRdRe) mC (O) ORb , -N (Ra) - (CRdRe) mC (O) NRaRb, -O- (CRdRe) mC (O) Rb, -O- (CRdRe) mC (O) ORb, and -O- (CRdRe) mC (O ) NRaRb; R2 and R3, at each occurrence, are each independently hydrogen or R4 alkyl is - (CH2) -OG or - (CH2) -N (Re) -G, where G, at each occurrence, is independently phenyl or pyridinyl , and each G is unsubstituted or independently substituted with 1 or 2 substituents independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, -CN, -NO2, -ORd, -S (Rd), -S (O) (alkyl), -S ( O) (haloalkyl), -S (O) 2 (alkyl), -S (O) 2 (haloalkyl), -NRdRe, -C (O) (Rd), -C (O) ORd, -C (O) NRdRe, -S (O) 2NRdRe, Rc, - (CRdRe) m-CN, - (CRdRe) m-NO2, - (CRdRe) m-ORd, - (CRdRe) mS (Rd), - (CRdRe) mS ( O) (alkyl), - (CRdRe) mS (O) (haloalkyl), - (CRdRe) mS (O) 2 (alkyl), - (CRdRe) mS (O) 2 (haloalkyl), - (CRdRe) m- NRdRe, - (CRdRe) mC (O) (Rd), - (CRdRe) mC (O) ORd, - (CRdRe) mC (O) NRdRe, - (CRdRe) mS (O) 2NRdRe, and - (CRdRe) m -Rc; Ra, at each occurrence, is independently hydrogen or alkyl; Rb, at each occurrence, is independently hydrogen, alkyl, haloalkyl, Rc or - (CRdRe) m-Rc; Rz, at each occurrence, is independently alkyl, haloalkyl , Rc or - (CRdRe) m-Rc; Rc, at each occurrence, is heteroaryl where heteroaryl is imidazolyl, triazolyl and tetrazolyl, where each Rc is unsubstituted or independently substituted with 1 or 2 substitutent it is independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, -CN, -NO2, -ORd, -S (Rd), -S (O) (alkyl), -S (O) (haloalkyl), -S (O) 2 (alkyl), -S (O) 2 (haloalkyl), -NRdRe, -C (O) (Rd), -C (O) ORd, -C (O) NRdRe, -S (O) 2NRdRe, - (CRdRe) m-CN, - (CRdRc) m-NO2, - (CRdRe) m-ORd, - (CRdRc) mS (Rd), - (CRdRe) mS (O) (alkyl ), - (CRdRe) mS (O) (haloalkyl), - (CRdRc) mS (O) 2 (alkyl), - (CRdRe) mS (O) 2 (haloalkyl), - (CRdRe) m-NRdRe, - ( CRdRe) mC (O) (Rd), - (CRdRe) mC (O) ORd, - (CRdRe) mC (O) NRdRe, and - (CRdRe) mS (O) 2NRdRe; Rd and Re, at each occurrence, are independently hydrogen or C1-C6 alkyl; and m is 1. |
| priorityDate | 2006-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 429.