| abstract |
A compound that is an indole derivative of formula (I) or a pharmaceutically acceptable salt thereof: wherein X is -SO2- or * -SO2NR3- wherein the bond labeled with an asterisk is linked to Ar1; R1 is hydrogen, fluoro, chloro, CN or CF3; R2 is hydrogen, fluoro or chloro; R3 is hydrogen, C1-C8 alkyl or C3-C7 cycloalkyl; Ar1 is a 5- or 6-membered heteroaryl group selected from furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl , pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl oheteroaryl groups are optionally substituted with one or more substituents independently selected from fluoro, chloro, CN, C3-C4 cycloalkyl, or -C (C1-C4 alkyl) or C1-C6 alkyl, the last two groups being optionally substituted with one or more fluoro atoms; Ar2 is a 5- or 6-membered heteroaryl group selected from pyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyr idinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted with one or more substituents independently selected from fluoro, chloro, CN, C3-C7 cycloalkyl, -O (C1-C4 alkyl) or C1-C6 alkyl, where the last two groups optionally substituted with one or more fluorine atoms. |