http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2384619-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc9d7e9a44d51faf66b84a23a5a34ba0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40a92325286ca98dbffa06d2c67ed064 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-02 |
| filingDate | 2005-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_875e8588c1885a99cbcc8c3d0a72248f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d970583b6dec4bc6094a8c763916e55f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_808cc838419d40830fb7a3eab96123be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b6ad88f5f18c3ce6980cb6cb565b2d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1604c5dabb5470049fe67062911a14e9 |
| publicationDate | 2012-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2384619-T3 |
| titleOfInvention | 1-aryl-4-substituted isoquinolines |
| abstract | A compound according to formula I ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, alkoxy of C1-C6, C1-C6 haloalkyl, C1-C6 haloalkoxy, (C3-C7 cycloalkyl) -C0-C4 alkyl; R2 is - (CRARB) OR4; R3 represents between 0 and 4 substituents, each of which is independently selects halogen, hydroxy, amino, cyano, optionally substituted alkyl, optionally substituted haloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted alkoxythio, optionally substituted haloalkoxy, optionally substituted alkoxyalkyl, mono- and di-substituted optionally substituted alkylamino, optionally substituted aminoalkyl, -E- (CRCRD) mZ, and -E- (CRCRD) m-XRA; R4 is: (i) C2-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, (C3-C7 cycloalkyl) -C0-C alkyl 4, mono- or di- (C1-C4-amino) -C2-C4 alkyl, (3-7 membered heterocycloalkyl) -C0-C4 alkyl, C0-C4 aryl-alkyl, or (heteroaryl) -alkyl C0-4, each of which is substituted with 0 to 4 substituents independently selected from Rx, C2-C4 alkanoyl, mono- and di- (C1-C4 alkyl) amino (C1-C4 alkyl), mono- and dialkyl C1-C4-amino (C1-C4 alkoxy), (3-7 membered heterocycloalkyl) C0-C4 alkyl and XRy; or (ii) joins R5 to form, with the nitrogen to which R4 and R5 are attached, a heterocycle having 1 to 3 rings, 5 to 7 ring members in each ring, in which the heterocycle is substituted with 0 to 4 substituents independently selected from Rx, oxo and WZ; R5 is: (i) hydrogen; (ii) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C7 carbocycle) -C0 alkyl -C4, each of which is substituted with 0 to 3 substituents independently selected from halogen, hydroxy, amino, cyano, C1-C4 alkyl, C1-C4 alkoxy, methylamino, dimethylamino, trifluoromethyl and trifluoromethoxy; or (iii) is attached to R4 to form, with the nitrogen to which R5 and R4 are attached, a heterocycle having 1 to 3 rings, 5 to 7 ring members in each ring, in which the heterocycle is substituted with 0 to 4 substituents independently selected from Rx, oxo and WZ; Ar is mono-, di- or tri-substituted phenyl, optionally substituted naphthyl, or optionally substituted heteroaryl, in which Ar is optionally substituted heteroaryl when R2 is -NR4R5; RA, RA 'and RB, which may be the same or different, are independently selected in each case from: (i) hydrogen hydroxy, and (ii) alkyl groups, cycloalkyl groups, and (cycloalkyl) alkyl groups, each of which is optionally substituted with one or more substituent (s) independently selected from oxo, hydroxy, halogen, cyano, amino, C1-6 alkoxy, -NH (C1-6 alkyl), -N (C1-6 alkyl) (C1 alkyl -6), -NHC (> = O) (C1-6 alkyl), -N (C1-6 alkyl) C (> = O) (C1-6 alkyl), -NHS (O) n (alkyl C 1-6), -S (O) n (C1-6 alkyl), - S (O) nNH (C1-6 alkyl), -S (O) nN (C1-6 alkyl) (C1 alkyl -6), and Z; Rx is independently selected, in each case, from halogen, hydroxy, amino, cyano, nitro, -COOH, -C (> = O) NH2, C1-C6-alkoxycarbonyl, mono- and di - (C1-6 alkyl) aminocarbonyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, mono- and di- (C1-C6 alkyl) amino, C1-C6 alkoxy, C1-C2 hydroxyalkyl , C1-C2 haloalkyl, C1-C2 haloalcoxide, (C3-C7 cycloalkyl) -C0-C4 alkyl, and -S (On) C1-C6 alkyl; |
| priorityDate | 2004-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 654.