| abstract |
Process for preparing acyclovir prodrugs by esterification of 9 (2-hydroxyethoxymethyl) -guanosine (Acyclovir) with an acylating agent in the presence of at least one solvent dialkylamide, characterized in that said dialkylamides are derived from carboxylic acids selected from the group consisting of capric acid, caprylic acid, caprinic acid, lauric acid, myristic acid, palmitic acid, palmoleic acid, stearic acid, cetearic acid, oleic acid, elaidinic acid, linolic acid, linoleinic acid, conjugated linoleic acid, ricinoleic acid, 12-hydroxystearic acid , gadoleinic acid, arachonic acid, erucic acid, behenic acid, lactic acid, glycolic acid or citric acid and mixtures thereof. |