abstract |
Compound of formula (I) ** Formula ** in which A and E represent the two C-R7 or one of the two ring members A and E represents N and the other represents C-R7, meaning R7 in each case hydrogen, fluorine or chlorine, Z represents O or S, n represents the number 0, 1 or 2, R1 represents (C1-C6) alkyl which may be substituted with hydroxyl, (C1-C4) alkoxy, amino, mono- or di - (C1-C4) alkylamino, hydroxycarbonyl, aminocarbonyl, cycloalkyl (C3-C6), 5 or 6 membered phenyl or heteroaryl or up to five times with fluorine, or represents alkenyl (C2-C6), cycloalkyl (C3-C6), 5 or 6-membered phenyl or heteroaryl, the above-mentioned cycloalkyl (C3-C6) groups may be substituted up to twice the same or differently with (C1-C4) alkyl, hydroxyl and (C1-C4) alkoxy and the phenyl and mentioned heteroaryl may be substituted up to twice the same or differently with fluorine, chlorine, cyano, (C1-C4) alkyl, difluoromethyl, trifluoromethyl, (C1-C4) alkoxy, difl uoromethoxy and / or trifluoromethoxy, R2 represents hydrogen, fluorine or chlorine, R3 represents cyano or a group of the formula -C (= O) -R8, -C (= O) -O-R8, -C (= O) - NH2 or -C (= O) -NH-R8, where R8 represents (C1-C6) alkyl, (C3-C6) alkenyl or (C3-C6) cycloalkyl, the (C1-C6) alkyl and the (C3-C6) cycloalkyl in turn substituted up to twice the same or differently with hydroxyl, (C1-C4) alkoxy, hydroxycarbonyl, (C1-C4) alkoxycarbonyl, amino, mono- and / or di-alkylamino ( C1-C4) and in the (C1-C6) alkyl and cycloalkyl (C3-C6) in each case a CH2 group can be replaced by an oxygen atom, if this results in a chemically stable compound, R4 represents methyl or ethyl or R3 and R4 are linked together and together form a condensed group of the formula in which * means the junction point with position 5, shown in formula (I), of the dihydropyrimidine ring and ** means the point of union with position 6, shown in the form the (I), of the dihydropyrimidine ring and R9 means hydrogen, (C1-C6) alkyl or cycloalkyl (C3-C6), the (C1-C6) alkyl being substituted by hydroxyl, (C1-C4) alkoxy, aminocarbonyl, aminocarbonylamino, acylamino (C1-C4) or cycloalkyl (C3-C6), |