| abstract |
A process for preparing ivabradine of formula (I) or its pharmaceutically acceptable salts, solvates or hydrate (I) ** Formula ** which comprises reacting 3-chloro-N - {[(7S) -3, 4-dimethoxybicyclo [4.2 .0] octa-1, 3, 5-trien-7-yl] methyl} -N-methylpropan1-amine of formula (IV) ** Formula ** with 7,8-dimethoxy-1, 3, 4, 5- tetrahydro-benzo [d] azepin-2-one of formula V or its alkaline salt ** Formula ** in the presence of a base in a suitable solvent to obtain ivabradine of formula (I), and, if desired, convert ivabradine of formula (I) in its pharmaceutically acceptable salts, solvate or hydrate forms. |