http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2381681-T3
Outgoing Links
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 |
filingDate | 2006-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2012-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59238ead1ba6de2deb6f46cdac8e10f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60f95026d5b7b5645b664265fb2ee3ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_979e577f5da710277f1e8d13c1ef94e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83903507338b5a478b344ea1802a0165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29fd5577435bb078ef5a1dd54839642b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c463b4586ac86774ee8f92b1c618fe74 |
publicationDate | 2012-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2381681-T3 |
titleOfInvention | 5-Phenyl-pentanoic acid derivatives as inhibitors of matrix metalloproteinase for the treatment of asthma and other diseases |
abstract | Compound which is: 5-biphenyl-4-yl-3-hydroxy-2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 1) , 2- (2 - {[(benzyloxy) carbonyl] amino} ethyl) -5-biphenyl-4-yl-3-hydroxypentanoic acid (compound No. 11), 5-biphenyl-4-yl-3-hydroxy-2 acid - {2- [(phenylacetyl) amino] ethyl} pentanoic acid (compound No. 45), 5-biphenyl-4-yl-3-hydroxy-2- [2- (1-oxophthalazin-2 (1H) -yl) ethyl ] pentanoic acid (compound No. 47), 5-biphenyl-4-yl-3-hydroxy-2- [2- (2'-oxospiro [cyclopropan-1, 3'-indole] -1 '(2H) -yl) ethyl] pentanoic acid (compound No. 49), 3-hydroxy-2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) ethyl] -5- [4'- (trifluoromethyl) biphenyl- 4-yl] pentanoic acid (compound No. 59), 5- (3 ', 4'-difluorobiphenyl-4-yl) -3-hydroxy-2- [2- (4-oxo-1, 2, 3-benzotriazin-] 3 (4H) -yl) ethyl] pentanoic acid (compound No. 60), 3-hydroxy-5- (4'-methoxybiphenyl-4-yl) -2- [2- (4-oxo-1, 2, 3- benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 64), 5- (4'-chlorobiphenyl-4-yl) -3-hydroxy-2- [2- ( 4-oxo-1,2,3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 65), 3-hydroxy-5- [4- (6-methoxypyridin-3-yl) phenyl] - 2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 67), 3-hydroxy-5- (4'-methylbiphenyl-4-yl ) -2- [2- (5-methyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] pentanoic acid (compound No. 68), 5- (4'-chlorobiphenyl- 4-yl) -3-hydroxy-2- [2- (5-methyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] pentanoic acid (compound No. 69), acid 3 -hydroxy-2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] -5- [4'- (trifluoromethoxy) biphenyl-4-yl] pentanoic acid (compound No. 70), 5- (4'-Fluorobiphenyl-4-yl) -3-hydroxy-2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid ( compound No. 71), 3-hydroxy-5- (4'-methylbiphenyl-4-yl) -2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 72), 5- (4'-cyanobiphenyl-4-yl) -3-hydroxy-2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 73), 5- (4'-Fluorobiphenyl-4-yl) -3-hydroxy-2- [2- (5-methyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] acid] pentanoic acid (compound No. 74), 3-hydroxy-5- [4- (6-methoxypyridin-3-yl) phenyl] -2- [2- (5-methyl-1, 3-dioxo-1,3-dihydro -2H-isoindol-2-yl) ethyl] pentanoic acid (compound No. 75), 5- (4'-ethylbiphenyl-4-yl) -3-hydroxy-2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 76), 3-hydroxy-2- [2- (5-methyl-1, 3-dioxo-1, 3-dihydro-2H-isoindole -2-yl) ethyl] -5- [4'- (trifluoromethyl) biphenyl-4-yl] pentanoic acid (compound No. 77), 5-biphenyl-4-yl-3-hydroxy-2- [2- (1 -oxo-4-phenyl-4a, 8a-dihydroftalazin-2 (1H) -yl) ethyl] pentanoic acid (compound No. 84), 5-biphenyl-4-yl-3-hydroxy-2- [2- (3- oxo-2, 3-dihydro-4H-1, 4-benzoxazin-4-yl) ethyl] pentanoic acid (compound No. 85), 5-biphenyl-4-yl-2- (2- [(3aR, 7aS) - 1,3-dioxo-1, 3, 3a, 4, 7, 7a-hexahydro-2H-isoindol-2-yl] ethyl} -3-hydroxypentanoic acid (compound No. 86), 5-biphenyl-4-yl-2 acid - (2 - {[(4-fluorophenyl) sulfoni l] amino} ethyl) -3-hydroxypentanoic acid (compound No. 87), 5-biphenyl-4-yl-2- (2 - {[(3-fluorophenyl) acetyl] amino} ethyl) -3-hydroxypentanoic acid (compound No. 88), 5-biphenyl-4-yl-2- {2- [(4-fluorobenzoyl) amino] ethyl} -3-hydroxypentanoic acid (compound No. 89), 5-biphenyl-4-yl-3-hydroxy- 2- [2- (5-methyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] pentanoic acid (compound No. 90), 5-biphenyl-4-yl-3- acid hydroxy-2- [2- (1-oxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] pentanoic acid (compound No. 91). 5-biphenyl-4-yl-2- [2- ({[(4-fluorophenyl) amino] carbonyl} amino) ethyl] -3-hydroxypentanoic acid (compound No. 92), 5-biphenyl-4-yl-2 acid - [2- (4, 4-dimethyl-2, 6-dioxopiperidin-1-yl) ethyl] -3-hydroxypentanoic acid (compound No. 93), 5-biphenyl-4-yl-2- [2- (7, 9-dioxo-8-azaspiro [4.5] dec-8-yl) ethyl] -3-hydroxypentanoic acid (compound No. 94), 5-biphenyl-4-yl-3-hydroxy-2- [2- (2-oxo -1,3-benzoxazol-3 (2H) -yl) ethyl] pentanoic acid (compound No. 96), 2- [2- (5-tert-butyl-1,3-dioxo-1, 3-dihydro-2H- isoindol-2-yl) ethyl] -3-hydroxy-5- [4- (6-methoxypyridin-3-yl) phenyl] pentanoic acid (compound No. 97), 5-biphenyl-4-yl-2- [2- (5, 6-dichloro-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] -3-hydroxypentanoic acid (compound No. 102), 5-biphenyl-4-yl-2- acid [2- (2, 4-dioxo-1, 4-dihydroquinazolin-3 (2H) -yl) ethyl] -3-hydroxypentanoic acid (compound No. 103), 5-biphenyl-4-yl-2- [2- ( 1,3-dioxo-1, 3-dihydro-2H-pyrrolo [3,4-c] pyridin-2-yl) ethyl] -3-hydroxypentanoic acid (compound No. 104), 2- [2- ( 5-tert-butyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] -5- (3 ', 4'-difluorobiphenyl-4-yl) -3-hydroxypentanoic acid (compound No. 105), (2R, 3S + 2S, 3R) -2- [2- (5-tert-butyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] - 5- (4'-fluorobiphenyl-4-yl) -3-hydroxypentanoic acid (compound No. 106), (2R, 3S + 2S, 3R) -2- [2- (5-tert-butyl-1, 3-dioxo-1 , 3-dihydro-2H-isoindol-2-yl) ethyl] -3-hydroxy-5- [4'- (trifluoromethyl) biphenyl4-yl] pentanoic acid (compound No. 107), acid (2R, 3R + 2S, 3S) -2- [2- (5-tert-butyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] -5- (4'-fluorobiphenyl-4-yl) -3-hydroxypentanoic acid (compound No. 108), (2R, 3R + 2S, 3S) -2- [2- (5-tert-butyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl ] -3-hydroxy-5- [4'- (trifluoromethyl) biphenyl4-yl] pentanoic acid (compound No. 109), acid (2R, 3R + 2S, 3S) -2- [2- (5-tert-butyl-1 , 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] -3-hydroxy-5- (4'-methylbiphenyl-4yl) pentanoic acid (compound No. 113), acid (2R, 3S + 2S , 3R) -2- [2- (5- tert-butyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethyl] -3-hydroxy-5- (4'-methylbiphenyl-4-yl) pentanoic acid (compound No. 114), acid (2R, 3R + 2S, 3S) -2- [2- (5-tert-butyl-1, 3-dioxo-1, 3-dihydro-2H-isoindole-2-yl) ethyl] -3-hydroxy-5 - (4'-Methoxybiphenyl-4-yl) pentanoic acid (compound No. 115), (2R, 3R + 2S, 3S) -2- [2- (5-tert-butyl-1,3-dioxo-1, 3-dihydro) -2H-isoindol-2-yl) ethyl] -5- (4'-chlorobiphenyl-4-yl) -3-hydroxypentanoic acid (compound No. 116), acid (2R, 3S + 2S, 3R) -2- [2- (5 -tert-butyl-1, 3-dioxo-1, 3-dihydro-2H-isoindol-2-yl) ethyl] -5- (4'-chlorobiphenyl-4-yl) -3-hydroxypentanoic acid (compound No. 117), acid ( 2R, 3S + 2S, 3R) -2- [2- (5-tert-butyl-1, 3-dioxo-1, 3-dihydro-2H-isoindole-2-yl) ethyl] -3-hydroxy-5- (4'-methoxybiphenyl-4-yl) pentanoic acid (compound No. 118), 5-biphenyl-4-yl-2- [2- (5-tert-butyl-1, 3-dioxo-1, 3-dihydro-2H- isoindol-2-yl) ethyl] -3-hydroxypentanoic acid (compound No. 121), 5-biphenyl-4-yl-3-hydroxy-2- [2- (1-oxo-1, 3-dihydro-2H-isoindole -2-yl) butyl] pentanoic (co No. 124), (2R, 3S) -3-hydroxy-5- [4- (6-methoxypyridin-3-yl) phenyl] -2- [2- (4-oxo-1, 2, 3-benzotriazin) -3 (4H) -yl) ethyl] pentanoic acid (compound No. 133), (2S, 3R) -3-hydroxy-5- [4- (6-methoxypyridin-3-yl) phenyl] -2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 134), (2R, 3R) -3-hydroxy-5- [4- (6-methoxypyridine- 3-yl) phenyl] -2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 135), or acid (2S, 3S) -3 -hydroxy-5- [4- (6-methoxypyridin-3-yl) phenyl] -2- [2- (4-oxo-1, 2, 3-benzotriazin-3 (4H) -yl) ethyl] pentanoic acid (compound No. 136); including racemates, enantiomers and diastereomers thereof, or a pharmaceutically acceptable salt thereof. |
priorityDate | 2005-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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