http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2381497-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-57545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 |
| filingDate | 2006-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e325932157a7f55d11548a972cf82f8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a91aede18f55dfbbcb0e616a1da81e92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55f79bd09fa7d8498c3f9b36e5b651cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c52935be54cef13a2a385fe88f3d5aa7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7f376f1e89679e276377dfdc440dfb5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6447a3d6c5640b7b1aadbd6c104bd0e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eadf569a5d09f295b0beb80e32575d9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c33b51eccaefe784f4fe3e6b71bd665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c36165599c10debd6604a4f6c1e7de82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da3415e71d8e062aef6ee652597ca628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d712707acbfffa7d8cdb6dd78588da80 |
| publicationDate | 2012-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2381497-T3 |
| titleOfInvention | Neuropeptide-2 receptor agonists |
| abstract | A neuropeptide-2 receptor agonist of formula (I) Y '| Y-R1-R2-X-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-NH2 (I), where: X is 4-oxo-6- acid ( 1-piperazinyl) -3 (4H) -quinazoline-acetic acid (Pqa), Y is H, an acyl portion, a substituted or unsubstituted alkyl, a substituted or unsubstituted lower alkyl, a substituted or unsubstituted aryl, a substituted heteroaryl or unsubstituted, a substituted or unsubstituted alkoxy, a poly (ethylene) glycol, PEGm-SSA, PEGm-ß-SBA, PEGm-SPA or PEGm-BTC portion, Y 'is H, a poly (ethylene) glycol portion, PEGm-SSA, PEGm-ß-SBA, PEGm-SPA or PEGm-BTC, R1 is Ile, Ala, (D) Ile, N-methyl Ile, Aib, 1-1Aic, 2-2Aic, Ach or Acp, R2 is Lys, Ala, (D) Lys, NMelys, Nle or (Lys-Gly), R3 is Arg, Ala, (D) Arg, N-methyl Arg, Phe, 3, 4, 5-trifluoro Phe or 2, 3, 4, 5, 6-Pentafluoro Phe, R4 is His, Ala, (D) His, N-methyl His, 4-MeOApc, 3-Pal or 4-Pal, R5 is Tyr, Ala, (D) Tyr, N- methyl Tyr, Trp, Tic, Bip, Dip, (1) Nal, (2) Nal, 3, 4, 5-trifluoro Phe or 2, 3, 4, 5, 6-pentafluoro Phe, R6 is Leu, Ala, ( D) Leu or N-methyl Leu, R7 e s Asn, Ala or (D) Asn, R8 is Leu or Trp, R9 is Val, Ala, (D) Val or N-methyl Val, R10 is Thr, Ala or N-methyl Thr, R11 is Arg, (D) Arg or N-methyl Arg, R12 is Gln or Ala, R13 is Arg, (D) Arg or N-methyl Arg, R14 is Tyr, (D) Tyr or N-methyl Tyr, Tyr-modified, Phe, Phe-modified , Cha, (1) Nal, (2) Nal, C-alpha-methyl Tyr or Trp, and PEGm has 1 to 60 KDa, or a pharmaceutically acceptable salt thereof, wherein the term "alkyl" means a radical branched or unbranched, cyclic or non-cyclic, saturated or unsaturated hydrocarbyl wherein said cyclic alkyl is C3 to C12, and wherein said non-cyclic alkyl is C1 to C10, the term "lower alkyl" means a branched or unbranched hydrocarbyl radical , cyclic or non-cyclic, saturated or unsaturated wherein said cyclic lower alkyl group is C5, C6 or C7, and wherein said non-cyclic lower alkyl group is C1, C2, C3 or C4; the term "alkoxy" means alkyl-O-; the term "aryl" means phenyl or naphthyl; and the term "heteroaryl" means a monocyclic or bicyclic radical of 5 to 12 ring atoms having at least one aromatic ring containing one, two or three ring heteroatoms chosen from N, O and S, the remaining ring atoms being C, with the understanding that the point of attachment of the heteroaryl radical will be in an aromatic ring and one or two ring carbon atoms of the heteroaryl group may be substituted by a carbonyl group. |
| priorityDate | 2005-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 546.