| abstract |
A compound of formula (I) R2CH3 CF3 (I) in which: R1 is an aryl or heteroaryl group, each optionally and independently substituted with one, two or three substituent groups selected from C1-C5 alkyl, aminocarbonyl, C1- alkylaminocarbonyl C5, C1-C5 dialkylaminocarbonyl, aminosulfonyl, C1-C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxyl, cyano and C1-C5 alkylthio, where the sulfur atom is optionally oxidized to a sulfoxide or a sulfone; R2 is C1-C5 alkylthio, where the sulfur atom is optionally oxidized to a sulfoxide or a sulfone, optionally and independently substituted with one, two or three substituent groups selected from halogen, hydroxy, oxo, cyano, alkoxyalkyl and aminocarbonyl; X is CH or N; and Y is CH or N, where X and Y are not both CH, or a tautomer, optical isomer, prodrug, co-crystal or salt thereof. |