http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2380135-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C275-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C265-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C265-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-40 |
| filingDate | 2007-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b658d75c04fc29856a593493784629e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48bc7e61e3861cec7b552ed381960c9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c71ffa472096810a7d7e286aa25492d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a830207e37c593a4522b65d64146628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e17f2c9cb160c7f940ecb4192c7b64d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3557104a38c0a3c31f06eb169a3d62b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_132794cffb643397c2fef3049d9c2835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_462b61fa111163fd23c6edea94d2f229 |
| publicationDate | 2012-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2380135-T3 |
| titleOfInvention | Method of preparation of phenylalanine derivatives having quinazolinadione skeleton and intermediates for their preparation |
| abstract | A method for preparing a phenylalanine derivative having a quinazolinadione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof, comprising the following steps (a), (b) and (c): wherein R1 represents a phenyl group that can have a substituent or a pyridyl group that can have a substituent; R2 represents an alkyl group that may have a substituent; R3 represents an alkyl group substituted with a dialkylamino group, an alkyl group substituted with a monoalkylamino group or an alkyl group substituted with an amino group; and R4 represents a hydrogen atom, an alkyl group or a benzyl group that may have a substituent; (a) reacting an acylphenylalanine derivative represented by the following formula (2) or a chemically acceptable salt thereof: in which R1 and R2 are the same as those defined above, with a reagent that introduces a carbonyl group and a derivative of anthranilic acid represented by the following formula (3) or a chemically acceptable salt thereof: in which R3 'represents an alkyl group substituted with a dialkylamino group, an alkyl group substituted with a monoalkylamino group which may have a protective group or a group alkyl substituted with an amino group which may have a protective group, to thereby form an asymmetric carboxy-urea derivative represented by the following formula (4) or a chemically acceptable salt thereof: in which R1, R2 and R3 ' no equal to those defined above; (b) converting the asymmetric carboxy-urea derivative of Formula (4) into a quinazolinadione derivative represented by the following formula (5) or a pharmaceutically acceptable salt thereof, in the presence of an agent that activates the carboxyl group: in the that from R1 to R3 'are the same as those defined above; and (c) if desired, replace an N-alkyl group with the hydrogen atom attached to the nitrogen atom present in the quinazolinadione ring of the quinazolinadione derivative of Formula (5) using an N-alkylation agent and then deprotect the resulting product, when the substituent R3 'is protected. |
| priorityDate | 2006-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 170.