http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2379308-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132aa5ddba376cda52c2bedb26765245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
filingDate | 2008-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2012-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfa3b31da4e0c25342b4d57b6bad210c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5b576d47ba32c3c9d4c475e2ded6323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc12727826a5f3a80b8b369c55c9360d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d9a94abebfec410c41f22826faad9e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0170b893725fb1cdb0a2e19017ebfe79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc84e115ce8ec4ccc6a78751c8ac9741 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_855c96798a17bdf3c8d0a99ef9e2587e |
publicationDate | 2012-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2379308-T3 |
titleOfInvention | Pirrolo [2,3-B] - and substituted pyrazolo [3,4-B] pyridines as adenosine receptor ligands |
abstract | Compound of formula (I) in which either A represents CR4 or N, in which R4 represents (C1-C4) alkoxycarbonyl, aminocarbonyl, mono (C1-C4) -aminocarbonyl or di-(C1-) alkyl C4) aminocarbonyl, and B represents NR5, in which R5 represents hydrogen or (C1-C4) alkyl, in which (C1-C4) alkyl may be substituted with a (C1-C4) alkoxy-carbonyl substituent, X represents O or S, R1 represents (C6-C10) aryl or 5-10 membered heteroaryl, in which aryl (C6-C10) and 5-10 membered heteroaryl can be substituted with 1 or 2 substituents independently selected from each other from the group of halogen, nitro, cyano, (C1-C6) alkyl, trifluoromethyl, hydroxy, (C1-C6) alkoxy, amino, mono (C1-C6) alkyl-amino, di (C1-C6) alkyl-amino, hydroxycarbonyl, (C1-C6) alkoxy-carbonyl, aminocarbonyl, mono (C1-C6) alkyl-aminocarbonyl, di-(C1-C6) -aminocarbonyl, pyrrolidino, piperidino, morpholino, piperazino and N'-alkyl (C1- C4) -piperazino, phenyl and heteroa 5 or 6-membered ryl, in which 5 or 6-membered phenyl and heteroaryl can be substituted with 1 to 3 substituents independently from each other selected from the group of halogen, nitro, cyano, (C1-C6) alkyl, difluoromethyl, trifluoromethyl, hydroxyl, (C1-C6) alkoxy, difluoromethoxy, trifluoromethoxy, amino, mono (C1-C6) -amino, di-(C1-C6) -amino, hydroxycarbonyl and (C1-C6) -carbonyl alkoxy, R2 represents C5-C6 cycloalkyl, 5 or 6 membered heterocyclyl, 5 or 6 membered phenyl or heteroaryl, in which cycloalkyl (C5-C6) can be substituted with 1 or 2 substituents independently from each other selected from the (C1) alkyl group -C6), hydroxyl, oxo, (C1-C6) alkoxy, amino, mono (C1-C6) -amino and di-(C1-C6) -amino alkyl, in which (C1-C6) alkyl and alkoxy (C1-C6) may be substituted with 1 or 2 substituents independently from each other selected from the group of hydroxyl, (C1-C4) alkoxy and cycloalkyl (C3-C7), in which Cycloalkyl (C3-C7) on the other hand can be substituted with 1 or 2 substituents independently from each other selected from the group of (C1-C4) alkyl, hydroxyl, oxo and alkoxy (C1-C4), and in which heterocyclyl of 5 or 6 members may be substituted with 1 to 3 substituents independently from each other selected from the group of oxo, thioxo, hydroxyl, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) alkyl, carbonyl, amino, mono-alkyl (C1-C6) -amino, di-(C1-C6) alkyl-amino and cycloalkyl (C3-C7), in which (C1-C6) alkyl may be substituted with 1 to 3 substituents independently from each other selected from the group of fluorine, oxo, hydroxy, trifluoromethyl, (C1-C4) alkoxy, (C1-C4) alkylcarbonyloxy, amino, mono (C1-C4) -amino, di (C1-C4) -amino and cycloalkyl ( C3-C7), in which cycloalkyl (C3-C7) on the other hand can be substituted with 1 or 2 substituents independently selected from each other from the group of (C1-C4) alkyl, hydroxyl, oxo and alkoxy (C1-C4), and in which (C1-C6) alkylcarbonyl may be substituted with a substituent selected from the hydroxyl and alkoxy (C1-C4) group, and in which cycloalkyl (C3-C7) may be substituted with 1 or 2 substituents independently from each other selected from the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, and in which 5 or 6 membered phenyl and heteroaryl can be substituted with 1 to 3 substituents independently from each other selected from the group of halogen, cyano, hydroxyl, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C7) cycloalkoxy and -NRARB, wherein (C1-C6) alkyl may be substituted with 1 to 3 substituents selected from the fluorine group, and in which (C1-C6) alkoxy may be substituted with 1 to 3 substituents independently selected from each other from the group of fluorine, trifluoromethyl, cycloalkyl (C3-C7), oxo, hydroxyl, (C1-C4) alkoxy, hydroxycarbonyl, amino, mono (C1-C4) alkyl-amino and di (C1-C4) -amino alkyl, and wherein (C3-C7) cycloalkoxy may be substituted with 1 or 2 substituents independently from each other selected from the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, and wherein RA represents hydrogen or (C1 -C6), in which (C1-C6) alkyl on the other hand may be substituted with a substituent selected from the group of hydroxyl and (C1-C4) alkoxy, RB represents hydrogen, (C1-C6) alkyl, (C3-) cycloalkyl C7), (C1-C4) -sulfonyl or cycloalkyl (C3-C7) sulfonyl, in which (C1-C6) alkyl on the other hand can be substituted with 1 or 2 substituents independently selected from each other selected from the cycloalkyl (C3) group -C7), oxo, hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, amino, mono (C1-C4) -amino and di (C1-C4) -amino, and in which (C3-C7) cycloalkyl ) on the other hand it may be substituted with 1 or 2 substituents independently from each other selected from the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, or in which two substitutes Adjacent phenylene together with the carbon atoms to which they are attached can form a 1,3-dioxolane or 2,2-difluoro-1,3-dioxolane, R3 represents hydrogen, (C1-C4) alkyl, alkoxy ( C1-C4), amino, mono (C1-C4) -amino, di-(C1-C4) amino or (C1-C4) -carbonyl alkyl as well as their N-oxides, salts, solvates, salts thereof N-oxides and solvates of the N-oxides. |
priorityDate | 2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 790.