http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2378071-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2005-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f564e44c42e710676604671e16957ac9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0b29a86afe46f98a149f24339a9bae5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_556ff8c221f87b3a458ff3b79a4f6e45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_126c78290897d682283060ed7ac0b94e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82fdd1f1af8cf3e928422da72ed33f00 |
| publicationDate | 2012-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2378071-T3 |
| titleOfInvention | Tetrahydro-indazole cannabinoid modulators |
| abstract | A compound having a structure according to formula I: in which the dashed lines between positions 2-3 and positions 3. 7a in formula I represent locations for two double bonds present when X1R1 is present; the dashed lines between positions 3-3a and positions 7. 1 in formula I represent locations for two double bonds present when X2R2 is present; X1 is absent, or is lower alkylene; X2 is absent, or is lower alkylene; in which only one of X1R1 and X2R2 is present; X3 is absent, or is lower alkylene, lower alkylidene or -NH-; X5 is absent, or is lower alkylene; R1 is selected from the group consisting of aryl, C3-C12 cycloalkyl or heterocyclyl, any of which is optionally substituted in one or more positions with halogen, lower alkyl, hydroxy or lower alkoxy; R2 is selected from the group consisting of aryl, C3-C12 cycloalkyl or heterocyclyl, any of which is optionally substituted in one or more positions with halogen, lower alkyl, hydroxy or lower alkoxy; R3 is R4 is CH-aryl, in which aryl is optionally substituted in one or more positions with hydroxy, lower alkyl, lower alkoxy or halogen; or CH-heterocyclyl, wherein heterocyclyl is optionally substituted in one or more positions with hydroxy, lower alkyl, lower alkoxy or halogen; R5 is hydrogen; hydroxy; lower alkyl; lower alkoxy; hydroxy-lower alkylene-; carboxy; alkoxycarbonyl; aryloxycarbonyl; aryl-alkoxycarbonyl; NHR10; -C (O) NR11R11a; -O-C (O) -R12; oxo; or -C (O) R13; R6 is absent, or is -CH (R6a) -; R6a is hydrogen; lower alkyl; or aryl optionally substituted with one or more of halogen, hydroxy, lower alkoxy, carboxy or alkoxycarbonyl; R7 is aryl optionally substituted with one or more hydroxy, halogen, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, -NH (R6a), aryloxy, arylalkoxy or aryl-lower alkylene; C3-C12 cycloalkyl optionally substituted with one or more hydroxy, halogen, lower alkyl, lower alkyl-aminocarbonyl, carboxy, alkoxycarbonyl, lower alkoxy, lower alkoxy-lower alkylene-, hydroxy-alkylene-, aryloxy, arylalkoxy, arylalkoxy-lower alkylene optionally substituted in aryl with one or more hydroxy, halogen or lower alkyl; or lower aryl alkylene; heterocyclyl optionally substituted with one or more hydroxy, halogen, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, lower alkoxy-lower alkylene-, hydroxy-alkylene-, aryloxy or arylalkoxy; each of R8, R8a, R9 and R9a is individually hydrogen; lower alkyl; -NHR15; aryl optionally substituted with one or more hydroxy, halogen, -NH (R6a), -SO2-NH (R6a), lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy or arylalkoxy; C3-C12 cycloalkyl optionally substituted with one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy, arylalkoxy or lower alkylene; or heterocyclyl optionally substituted with one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy or arylalkoxy; R10 is hydrogen, C1-C10 alkoxycarbonyl optionally substituted in one or more positions with hydroxy, halogen or aryl; -C (O) CF3; -SO2-NR14R14a; -C (O) -heterocyclyl optionally substituted in one or more positions with hydroxy, halogen or aryl; -C (O) NR14R14a; -SO2-aryl; -SO2R14; or SO2NR14R14a; each of R11, R11a, R12, R13, R14 and R14a and R15 is individually hydrogen; C1-C10 alkyl; heterocyclyl; C3-C12 cycloalkyl; or aryl optionally substituted with lower alkyl, hydroxy, alkoxy, halogen -SO2-N (R6a) 2, heterocyclyl or aryl-lower alkylene-; Z1 is absent; -NH-; or is lower alkylene optionally substituted in one or more positions with halogen, hydroxy, lower alkoxy, carboxy or lower alkoxycarbonyl; Z2 is absent; or is lower alkylene optionally substituted in one or more positions with aryl, cycloalkyl, halogen, hydroxy, lower alkyl, lower alkoxy, carboxy, alkoxycarbonyl or aryl; or a pharmaceutically acceptable salt, isomer or polymorph thereof, in which the term "lower" refers to radicals of up to 4 carbon atoms. |
| priorityDate | 2004-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 780.