abstract |
A compound of formula (D) having the structure: in which: La is CH2, O, NH or S; Ar is a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl; Y is an optionally substituted group selected from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl; Z is C (= O), OC (= O), NHC (= O), C (= S), S (= O) x, OS (= O) x, NHS (= O) x, where x is 1 or 2; R is H or C1-C6 alkyl; and R7 and R8 are H or taken together form a bond; R6 is H, or a pharmaceutically acceptable salt thereof. |