http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2376108-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_562e4af016953c0a80e09960559ed0d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91ff5909f4c7bde673e1f90292ac93dc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
| filingDate | 2005-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3bf412c826ee50aba56176bcdd9ad01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2559aabcee25907081e520536e6a77b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc23d8a5782000f301a381454524d343 |
| publicationDate | 2012-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2376108-T3 |
| titleOfInvention | COMPOUNDS, COMPOSITIONS AND METHOD TO INHIBIT THE TOXICITY OF A-SINUCLEIN. |
| abstract | A compound of Formula I ** Formula ** or a pharmaceutically acceptable salt thereof, in which: X is O, S or NR, wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or aralkyl; Y is NRR 'or OH; wherein R 'is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or aralkyl; Z is a direct bond or NR; R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, aralkenyl, heteroaralkyl or heteroaralkenyl; n is from 0 to 4; R2 is selected from (i) or (ii) as follows: (i) hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl , heterocyclyl, C (A) R110, halo, pseudohalo, OR111, S (D) aR112, NR115R116 or N + R115R116R117; or (ii) any two R2 groups, which substitute adjacent atoms in the ring, together form alkylene, alkenylene, alkynylene or heteroalkylene; A is O, S or NR125; R110 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl , cycloalkyl, heterocyclyl, C (A) R126, halo, pseudohalo, OR125, SR125, NR127R128 and SiR122R123R124; R111 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, C (A) R1 and SiR122R123R124; D is O or NR125; a is 0, 1 or 2; when a is 1 or 2, R112 is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, halo, pseudohalo, OR125, SR125 and NR132R133; when a is 0, R112 is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, SR125 and C (A) R129; each of R115, R116 and R117 is independently select between (a) and (b) as follows: (a ) hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, C (A) R129, OR125 or NR132R133; or (b) any two of R115, R116 and R117 together form alkylene, alkenylene, alkynylene, heteroalkylene and the other is selected as in (a); R122, R123 and R124 are selected as in (i) or (ii) as indicates below: (i) each of R122, R123 and R124 is independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, OR125 or NR132R133; or (ii) any two of R122, R123 and R124 together form alkylene, alkenylene, alkynylene, heteroalkylene; and the other is selected as in (i); R125 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl or heterocyclyl; R126 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl , OR125 or NR134R135; wherein each of R134 and R135 is independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, OR136 or NR132R133, or R134 and R135 together form alkylene, alkenylene, alkynylene, heteroalkylene, in which R136 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl or heterocyclyl; R127 and R128 are selected as in (i) or (ii) as follows: (i) each of R127 and R128 is independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, OR125, NR137R138 or C (A) R139, wherein each of R137 and R138 is independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl or heterocyclyl, or together form alkylene, alkenylene, alkynylene, heteroalkylene; and R139 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, OR140 or NR132R133, wherein R140 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl; or (ii) R127 and R128 together form alkylene, alkenylene, alkynylene, heteroalkylene; R129 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, OR140 or NR132R133; each of R130 and R131 is independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl or C (A) R141, wherein R141 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl , heterocyclyl, OR125 or NR132R133; or R130 and R131 together form alkylene, alkenylene, alkynylene, heteroalkylene; each of R132 and R133 is independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroaryl, cycloalkyl, heterocyclyl, or R132 and R133 together form alkylene, alkenylene, alkynylene, heteroalkylene; and R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; wherein each of X, Y, Z, R1, R2 and R3 is independently unsubstituted or substituted with one or more substituents, in one embodiment one, two or three substituents, each independently selected from Q1, in which Q1 it is halo, pseudohalo, hydroxy, oxo, aunt, nitrile, nitro, formyl, mercapto, hydroxycarbonyl, hydroxycarbonylalkyl, hydroxycarbonylalkyl, alkyl, haloalkyl, polyhaloalkyl, aminoalkyl, diaminoalkyl, alkenyl containing 1 to 2 double bonds, alkynyl 2 triple bonds, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, aralkyl, aralkenyl, aralkynyl, heteroarylalkyl, trialkylsilyl, dialkylarylsilyl, alkyldiarylsilyl, triarylsilyl, alkylidene, arylalkylidene, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, alcoxixarbonilalcoxi, aryloxycarbonyl , aryloxycarbonylalkyl, aralkoxycarbonyl, aralkoxycarbonylalkyl, ar alkoxycarbonylalkoxy, arylcarbonylalkyl, aminocarbonyl, aminocarbonyl, aminocarbonyl alkylaminocarbonyl, alkylaminocarbonylalkyl, alquilaminocarbonilalcoxi, dialkylaminocarbonyl, dialkylaminocarbonylalkyl, dialquilaminocarbonilalcoxi, arylaminocarbonyl, arylaminocarbonylalkyl, arilaminocarbonilalcoxi, diarylaminocarbonyl, diarilaminocarbonilalquilo, diarilaminocarbonilalcoxi, arylalkylaminocarbonyl, arilalquilaminocarbonilalquilo, arilalquilaminocarbonilalcoxi, alkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, cycloalkoxy, perfluoroalkoxy, alkenyloxy, alkynyloxy, aralkoxy, alkylcarbonyloxy, arylcarbonyloxy, aralkylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, aralcoxicarboniloxi, aminocarbonyloxy, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alquilarilaminocarboniloxi, diarilaminocarboniloxi, guanidino, isothioureido, ureido, N-alkylureido, N-arylureido, N'-alkylureido , N ', N'-dialkylureido, N'-alkyl-N'-arylureido, N', N'- diarylureido, N'-arylureido, N, N'-dialkylureido, N-alkyl-N'-arylureido, N-aryl-N'-alkylureido, N, N'-diarylureido, N, N ', N'-trialkylureido, N , N'-dialkyl-N'-arylureido, N-alkyl-N ', N'-diarylureido, N-aryl-N', N'-dialkylureido, N, N'-diaryl-N'- alkylureido, N, N ', N'-triarilureido, amidino, alkylamidino, arilamidino, aminothiocarbonyl, alkylaminothiocarbonyl, arylaminothiocarbonyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, arylaminoalkyl, diarylaminoalkyl, alkylarylaminoalkyl, alkylamino, dialkylamino, haloalkylamino, arylamino, diarylamino, alkylarylamino, alkylcarbonylamino, alkoxycarbonylamino, aralkoxycarbonylamino , arylcarbonylamino, arylcarbonylaminoalkyl, ariloxicarbonilaminoalquilo, ariloxiarilcarbonilamino, aryloxycarbonylamino, alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, heterocyclylsulfonylamino, heteroarylthio, azido, -N + R151R152R153, P (R150) 2, P (= O) (R150) 2, OP (= O) ( R150) 2, -NR160C (= O) R163, dialkylphosphonyl, alkylaryl phosphonyl, diarilfosfonilo, hidroxifosfonilo, alkylthio, arylthio, perfluoroalkylthio, hydroxycarbonylalkylthio, thiocyano, isothiocyano, alquilsulfiniloxi, alkylsulfonyloxy, arilsulfiniloxi, arylsulfonyloxy, hydroxysulfonyloxy, alcoxisulfoniloxi, aminosulfonyloxy, alquilaminosulfoniloxi, dialquilaminosulfoniloxi, arilaminosulfoniloxi, diarilaminosulfoniloxi, alquilarilaminosulfoniloxi, alkylsulfinyl, alkylsulfonyl, arylsulfinyl, arylsulfonyl, hydroxysulfonyl, alkoxysulfonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, diarylaminosulfonyl or alkylaminosulfonyl; azido, tetrazolyl or two Q1 groups, which substitute atoms in a 1,2 or 1,3 arrangement, together form alkylenedioxy (i.e. -O- (CH2) and O-), thioalkyleneoxy (i.e. -S- (CH2) yO-) or alkylenedithioxy (ie, -S- (CH2) and S-) in which y is 1 or 2; or two groups Q1, which replace the same carbon atom, together form alkylene; and each of Q1 is independently unsubstituted or substituted with one or more substituents, in an embodiment one, two or three substituents, each independently selected from Q2; Each Q2 is independently halo, pseudohalo, hydroxy, oxo, aunt, nitrile, nitro, formyl, mercapto, hydroxycarbonyl, hydroxycarbonylalkyl, hydroxycarbonylalkyl alkyl, haloalkyl, polyhaloalkyl, aminoalkyl, diaminoalkyl, alkenyl containing 1 to 2 double bonds containing 1 to 2 triple bonds, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, aralkyl, aralkenyl, aralkynyl, heteroarylalkyl, trialkylsilyl, dialkylarylsilyl, alkyldiarylsilyl, triarylsilyl, alkylidene, arylalkylidene, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, aryloxycarbonyl, aryloxycarbonylalkyl, aralkoxycarbonyl, aralkoxycarbonylalkyl, arylcarbonylalkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl, diarylaminocarbonyl, arylalkylaminocarbonyl, alkoxy, aryloxy, heteroaryloxy, heterocycloalkoxy, heterocycloalkoxy coxy, alkenyloxy, alkynyloxy, aralkoxy, alkylcarbonyloxy, arylca |
| priorityDate | 2004-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 321.