http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2375913-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2009-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5933839ad5e6cf8b543b6bb1e648f4da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a25500bd8f8c2ab967bcd31f0d688d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaab115647e684ea47b72d8be74f78e4 |
| publicationDate | 2012-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2375913-T3 |
| titleOfInvention | NEW CLASS OF SPIROPIPERIDINS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES. |
| abstract | A compound of formula I: wherein the stereochemistry shown in formula I in the carbon bonded to R2 and in the spirocyclic carbon is the absolute stereochemistry; B is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, in which B is optionally substituted with zero to three R4 groups; Z is (CH2) n-Op- (CH2) qo a cycloalkylene moiety, with the proviso that when Z is (CH2) n-Op- (CH2) q, the terminal methylene of the chain (CH2) n is attached to the piperidinyl ring nitrogen; A is independently aryl, cycloalkyl, heterocycloalkyl or heteroaryl, wherein said aryl, cycloalkyl, heterocycloalkyl, or heteroaryl group is optionally substituted with one to three R1; each R1 is independently alkyl, halogen, cyano, SO2NHR9, CON (R8) 2, N (R8) COR8, SO2N (R8) 2, N (R8) SO2R8, COR8, SO2R8, cycloalkyl- (CH2) r, heterocycloalkyl- ( CH2) t, aryl- (CH2) t, heteroaryl- (CH2) t, (CH2) tN (R9) 2 or (CH2) t-OR6 in which each R1 alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- ( CH2) t, aryl- (CH2) to heteroaryl- (CH2) t is optionally substituted independently with cyano, alkyl, halogen or OR6; R2 is alkyl, cycloalkyl or alkenyl in which said alkyl, cycloalkyl or alkenyl is optionally substituted by halogen, hydroxyl or cyano; R3A and R3B are each independently hydrogen, aryl, heteroaryl or alkyl optionally substituted with R1; or R3A and R3B together with the carbon to which they are attached form a C = O, C = NR8, a cycloalkylene moiety or a heterocycloalkylene moiety; each R4 is independently halogen, hydroxyl, cyano, halo, O-alkyl, O-cycloalkyl, SO2R8, N (R8) 2, COR8, CON (R8) 2, alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t, wherein said R4 alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t is optionally substituted with R1; each R5 is independently hydrogen alkyl, alkenyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2), aryl- (CH2) to heteroaryl- (CH2) t, wherein said substituent R5 alkyl, alkenyl, cycloalkyl- (CH2 ) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t is optionally substituted with one or more hydroxyl, aryl, heteroaryl, halogen, alkyl, cycloalkyl, SO2R8-NR8COR8, -CON (R8 ) 2, COOR8, -C (O) R8, -CN or N (R8) 2, wherein said aryl, alkyl, cycloalkyl and heteroaryl substituents are optionally substituted with one or more halogen, alkyl, hydroxyl or -O-alkyl ; each R6 is independently hydrogen, alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t in which said cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t is optionally substituted with one to three R7; each R7 is independently alkyl, hydroxy, alkoxy, halogen, cyano, amino, alkylamino, dialkylamino, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) t or heteroaryl- (CH2) t; each R8 is independently hydrogen, alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t, wherein said cycloalkyl- (CH2) t, heterocycloalkyl- (CH2 ) t, aryl- (CH2) to heteroaryl- (CH2) t are optionally substituted with alkyl, halo or cyano; R9 is hydrogen or alkyl; n is an integer selected from 1, 2 and 3; p is an integer selected from 0 to 1, with the proviso that if p is 1, then n is 2 or 3; q is an integer selected from 0 to 1, with the proviso that if p is 0, then q is 0; t is an integer independently selected from 0, 1, 2 and 3; or its pharmaceutically acceptable salts. |
| priorityDate | 2008-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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