| abstract |
A compound, or a pharmaceutically acceptable salt of the compound, in which the compound has the structure of Formula II: wherein: X is selected from the group consisting of -CH2- and -O-, Z is selected from the group consisting of -C (R 81) - and -N-; R 1 is selected from the group consisting of cyclopentyl, cyclobutyl and phenyl; wherein the R 1 cyclopentyl, cyclobutyl and phenyl substituents may be optionally substituted with one or more substituents independently selected from the group consisting of chloro, fluoro, methyl, ethyl, propyl, chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl and trifluoromethyl ; where: R 2 is selected from the group consisting of hydrogen or (C1-C4) alkyl, R 5 is selected from the group consisting of- (CH2) mOR 50, - (CH2) mC (O) OR 50 and - (CH2) mC (O) NR 51 R 52, m is 0, 1, 2 or 3; R 50 is selected from the group consisting of hydrogen and (C1-C6) alkyl; R 51 and R 52 are independently selected from the group consisting of hydrogen and (C1-C6) alkyl; wherein the substituents R 50, R 51 and R 52 (C1-C6) alkyl may be independently and optionally substituted with one or more substituents selected from the group consisting of halogen, -OR 53, -C (O) R 53, - C (O) OR 53, - C (O) NR 54 R 55, -NR 54 R 55, -N (R 56) C (O) R 53; -S (O) pR 53 and -S (O) pNR 54 R 55; p is 0, 1 or 2; R 53 is selected from the group consisting of hydrogen, (C1-C6) alkyl, halo (C1-C6) alkyl, hydroxyalkyl (C1-C6) and carboxy-(C1-C6) alkyl; R 54 and R 55 are independently selected from the group consisting of hydrogen, (C1-C6) alkyl, halo (C1-C6) alkyl, hydroxy (C1-C6) alkyl and carboxy (C1-C6) alkyl; and R 81, R 82, R 83, R 84 and R 85 are independently selected from the group consisting of hydrogen, chlorine, fluoro, cyano, hydroxy, carboxy, methyl, ethyl, trichloromethyl, trifluoromethyl, cyanomethyl, hydroxymethyl, carboxymethyl, methoxy, amino, methylamino and dimethylamino. |