abstract |
A nucleic acid comprising a non-specific promoter and a sequence encoding a recombinant antibody, in which the antibody molecule has heterologous T lymphocyte epitopes therein so that the antibody cannot take its native conformation when the acid is expressed nucleic, the heterologous T lymphocyte epitopes being: GTGRAMLGTHTMEVTVYH at CDRH1 and CDRL3 SVYDFFVWL at CDRH2, and WNRQLYPEWTEAQRLD at CDRH3 and CDRL1. |