http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2375111-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2003-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e9c1396640fb05fd01b1c2df3639a3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70270a090ae1d77a3242c4c1034cd11b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6b0d0bae423ba610594ec240c11bd93 |
| publicationDate | 2012-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2375111-T3 |
| titleOfInvention | PYRIMIDINES 2,4,6-TRISUSTITUIDAS AS INHIBITORS OF FOSFOTIDILINOSITOL (PI) 3-QUINASA AND ITS USE IN THE TREATMENT OF C�? NCER. |
| abstract | A compound having the formula I: or a pharmaceutically acceptable stereoisomer, tautomer, salt or ester thereof, wherein Y is selected from the group consisting of (1) substituted or unsubstituted aryl, (2) substituted or unsubstituted heterocyclyl, and ( 3) substituted or unsubstituted heteroaryl; X is selected from the group consisting of (1) -N (R1x) -, (2) - (CH2) mC (R2x, R3x) -N (R1x) -, (3) -0-, (4) -S- , (5) -SO-, (6) -SO2-, (7) -C (R2x, R3x) -, and (8) where R1x, R2x, and R3x are selected from the group consisting of (a) H, ( b) C1-C6-substituted or unsubstituted alkyl, (c) C2-C6-substituted or unsubstituted alkenyl, (d) C2-C6-substituted or unsubstituted alkynyl, (e) substituted or unsubstituted aryl, (f) substituted or unsubstituted heterocyclyl, (g) substituted or unsubstituted heteroaryl; and m is 0, 1, 2, 3, or 4; R1 is selected from the group consisting of (1) H, (2) C1-C6-substituted or unsubstituted alkyl, (3) -COOH, (4) halo, (5) -OR1t, and (6) -NHR1t, where R1t is H or C1-C6-alkyl; R2 is selected from the group consisting of (1) substituted or unsubstituted aryl, and (2) substituted or unsubstituted heteroaryl, W is selected from the group consisting of (1) -N (R1w, R2w), and (2) where R1w and R2w are selected from the group consisting of (a) substituted or unsubstituted aryl, (b) substituted or unsubstituted heterocyclyl, and (c) substituted or unsubstituted heteroaryl, Z is selected from the group consisting of (a) -O-, (b) -NRz-, (c) -S-, (d) -SO-, and (e) -SO2-, where Rz is H or substituted or unsubstituted alkyl group; and R4w is selected from the group consisting of (a) H, (b) C1-C6-substituted or unsubstituted alkyl, (c) -COOR5w, (d) -CONH2, (e) -OR5w, and (f) -NHR5w , where R5w is H or C1-C6-alkyl; and r is 0.1, or 2; with the proviso that when R2 is phenyl independently substituted with one or two substituents selected from hydrogen, cycloalkyl, heterocycloalkyl, halo, nitro, amino, sulfonamido, or alkylsulfonylamino, R1 is hydrogen, haloalkyl, alkyl, or halo, and X is NR1x , then Y is substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl. |
| priorityDate | 2002-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 768.