| abstract |
A compound of formula (I): wherein, each R1 is independently selected from hydroxy, halo, C1-6 alkyl, C1-6 alkoxy, (C1-6 alkyl) sulfanyl, (C1-6 alkyl) sulfonyl, cycloalkyl, heterocycloalkyl, phenyl, and heteroaryl; R2 is C1-6 alkyl or halo (C1-6 alkyl); each R3 is independently selected from halo, C1-6 alkyl, and C1-6 alkoxy; each R4 is independently selected from hydroxy, C1-6 alkyl, C1-6 alkoxy, halo, heterocycloalkylcarbonyl, carboxyl, (C1-6 alkoxy) carbonyl, aminocarbonyl, C1-6 alkylaminocarbonyl, carbonitrile, cycloalkyl, heterocycloalkyl, phenyl, and heteroaryl ; wherein R1, R2, R3, and R4 may optionally be substituted with one or more substituents independently selected from hydroxy, halo, C1-6 alkyl, halo (C1-6 alkyl), C1-6 alkoxy, and halo (C1 alkoxy - 6); a is 1, 2, 3, 4, or 5; b is 0, 1, 2, or 3; and c is 1 or 2; or a tautomer, stereoisomer, polymorph, or ester thereof or a pharmaceutically acceptable salt of the compound, tautomer, stereoisomer, polymorph or ester. |