http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2374449-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 |
| filingDate | 2006-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2310333a8479c5c687160e281fcd1da5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6aa4c89df244527f387d994e61e0c1d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64f3f47b88748990180df97c3b3347d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae81f62e44d1f9196efcc94bf0e0f89f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_791a45a4d9552723b24d9d827f0a0179 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4929ab6755f732293d20cf9b7ac9e66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08875fa89cac664543f103097de3ac27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29a7b1a1d97a398b4d0bf1c235a481d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_717f5c7128d44b0e9fca22547f480b71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79bf515cbb8a8ba554cc4f8dbe077469 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a26dfd7db892501ee2696a00bbf03fd7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17dadcddf576f4bc77ffdacfb318b1e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79f07066e323bb8910da388a4df6f797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fba537c022120979d54a765ba02648f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0df3291781de963fd115dd3c31add267 |
| publicationDate | 2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2374449-T3 |
| titleOfInvention | IMIDAZOL COMPOUNDS REPLACED AS KSP INHIBITORS. |
| abstract | A compound of formula I: wherein: R 1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, alkyl, and substituted alkyl, with the proviso that the substituted alkyl is not substituted with substituted aryl or aryl; R2 is selected from the group consisting of hydrogen alkyl, and aryl; R3 and R4 are independently selected from the group consisting of hydrogen hydroxy, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic, since only 1 of R3 or R4 is hydroxy; or R3 and R4 together with the nitrogen atom attached thereto join to form a substituted heterocyclic or heterocyclic; R5 is selected from the group consisting of hydrogen alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; or R1 and R5, together with the carbon and nitrogen atoms bonded respectively thereto join to form a substituted heterocyclic or heterocyclic group; or when R1 and R5, together with the carbon and nitrogen atoms bonded thereto respectively, do not form a heterocyclic group, and then R4 and R5, together with the atoms attached thereto, form a substituted heterocyclic or heterocyclic group; R8 is selected from the group consisting of L-A1, where L is selected from the group consisting of -S (O) q where q is one or two, and C1 to C5 alkylene optionally substituted with hydroxy, halo, or acylamino; and A1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl; and one or both of R6 or R7 is selected from the group consisting of cycloalkyl, heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with - (R9) m where R9 is as defined herein and m is an integer from 1 to 4 , and the other or R6 or R7 is selected from the group consisting of halo hydrogen, and alkyl; R9 is selected from the group consisting of cyano, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, -CF3, alkoxy, substituted alkoxy, halo, and hydroxy; and when m is an integer from 2 to 4, and then each R9 can be the same or different; or pharmaceutically acceptable salts or esters thereof. |
| priorityDate | 2005-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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