| abstract |
Compound of formula (I): 5 10 15 20 or a pharmaceutically acceptable salt thereof, wherein: X is S or O; Ar2 is R1 is -CF3, -NO2, or -CN; each R7 is independently -H, - (C1-C6) alkyl, - (C2-C6) alkenyl, - (C2-C6) alkynyl, - (C3-C8) cycloalkyl, - (C5-C8) cycloalkenyl, -phenyl, -heterocycle (3 to 5 members), -C (halo) 3, -CH (halo) 2, or -CH2 (halo); each R8 is independently - (C1-C6) alkyl, - (C2-C6) alkenyl, - (C2-C6) alkynyl, - (C3-C8) cycloalkyl, - (C5-C8) cycloalkenyl, phenyl, -heterocycle (3 5 members), C (halo) 3, -CH (halo) 2, or -CH2 (halo); each R9 is independently - (C1-C6) alkyl, - (C2-C6) alkenyl, - (C2-C6) alkynyl, - (C3-C8) cycloalkyl, - (C5-C8) cycloalkenyl, phenyl, C (halo) 3, -CH (halo) 2, or -CH2 (halo), -CN, -OH, -halo, -N3, -NO2, -CH = NR7, -NR7OH, -OR7, - COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, -SR7, -S (O) R7, or -S (O) 2R7; each R11 is independently -CN, -OH, - (C1-C6) alkyl, - (C2-C6) alkenyl, - (C2-C6) alkynyl, -halo, -N3, -NO2, -N (R7) 2, -CH = NR7, -NR7OH, -OR7, -COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, SR7, -S (O) R7, or -S (O) 2R7; each halo is independently -F, -Cl, -Br, or -I; q is an integer that varies from 0 to 6; r is an integer that varies from 0 to 5; and t is 1 or 2. |