http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2373561-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a7f3068c412965d1d753bd152f94fe |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 |
| filingDate | 2005-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fd1001112efe2fff71257d6dc01f9ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65d0397e703fe6b321c76252c80d074e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2242c4a3434a9928c3b05b92cb292455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd539764b7c49edebafe9a71932b4bc5 |
| publicationDate | 2012-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2373561-T3 |
| titleOfInvention | USE OF DERIVATIVES OF 1,4-BIS (3-AMINOALQUIL) PIPERAZINE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES. |
| abstract | Use of a compound of formula (I) in which n and m are identical or different, and independently represent an integer greater than or equal to 2, the resulting hydrocarbon chain optionally comprising one or more heteroatoms selected from oxygen, nitrogen and sulfur, and wherein R1, R2, R3 and R4, independently of each other, represent - a hydrogen atom, - a linear or branched, saturated or unsaturated (C1-C7) alkyl group, - a (C1-C7) alkyl group ) carbonyl, - an aryl group, - an aralkyl group, in which the aryl group is attached to an (C1-C7) alkyl moiety that bridges, - a heteroaryl group, in which each (C1) alkyl group -C7) may be substituted with one or more identical or different groups selected from a halogen, the cyano group, the hydroxy group, the nitro group, the amino group, an amino (C1-C7) alkyl group, an alkoxy group of (C1-C4), a terbutoxycarbonylamino group, a HO-alkyl group of (C1-C8) - , an H2N-alkyl group of (C1-C8) -, a group HO- (C = O) -, an alkyl group of (C1-C8) -O- (C = O) -, an alkyl group of (C1 - C8) - (C = O) -, an alkyl group of (C1-C8) - (C = O) -alkyl of (C1-C8) -, an HSO3-alkyl group of (C1-C8) -, a group H2N- (C = O) - and a group H2N- (C = O) -alkyl of (C1-C8) -, in which the aryl group is selected from the benzyl, phenyl, biphenyl, antryl, phenylbenzyl groups , fluorenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indenyl and indanyl, in which the heteroaryl group is an aromatic monocycle, an aromatic bike, an aromatic tricycle, or a bike or a tricycle, of which one or two of the cycles is aromatic and the other or other cycles are partially hydrogenated, from C5 to C14, which comprises, in the cyclic system, one, two or three heteroatoms, identical or different, selected from oxygen, nitrogen and sulfur, and in which each of these aryl or heteroaryl groups possibly comprise one or more identical substitutions. or different, selected from a halogen, the hydroxy group, an alkyl group of (C1-C7), an alkoxy group of (C1-C7), an arialkoxy group of (C7-C13), the cyano group, the nitro group , the amino group, an alkyl (C1-C7) amino group, an HO-alkyl group of (C1-C8) -, an H2N-alkyl group of (C1-C8) -, an HO- (C = O) group -, an alkyl group of (C1-C8) -O- (C = O) -, an alkyl group of (C1-C8) - (C = O) -, an alkyl group of (C1-C8) - (C = O) -alkyl of (C1-C8) -, an HSO3-alkyl group of (C1-C8) -, an H2N- (C = O) group - and an H2N- (C = O) -alkyl group of ( C1-C8) -, in which (R1 and R2) and / or (R3 and R4), independently of each other, may possibly form an aromatic or partially or fully hydrogenated C4 to C14 monocycle, optionally comprising within the cyclic system one, two or three heteroatoms, identical or different, selected from oxygen, nitrogen and sulfur, provided that a maximum of two of the radicals selected from R1, R2, R3 and R4 represent simultaneously a hydrogen atom, and that (R1 and R2) or (R3 and R4) do not simultaneously represent a hydrogen atom, or its salts with pharmaceutically acceptable acids, for the preparation of a pharmaceutical composition for use in the treatment of pathologies related to amyloidopathies, tauopathies and synucleopathies |
| priorityDate | 2004-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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