http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2372067-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c851e729089df9a427027272fa290 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2006-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26100be7e175c11c93f984feba1d0ab4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0685c55a22c0dce42a9fb8eeb289d201 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_970ce8d9355f5591be06d570a4194062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebce64b7dcf479a9cee3496e52efa54b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4930955cdcae0e0e254e5df88e3c1de5 |
| publicationDate | 2012-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2372067-T3 |
| titleOfInvention | ISOQUINOLONE CYCLHEXYLAMINE DERIVATIVES AS INHIBITORS OF RHO-QUINASA. |
| abstract | A compound of the formula (I) or of the formula (I ') in which R1 is H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, [(C1-C6) alkylene ] 0-1-cycloalkyl (C3-C8), [alkylene (C1-C6)] 0-1-heterocyclyl (C5-C10), [alkylene (C1-C6)] 0-1-aryl (C6-C10), C (O) -alkyl (C1-C6), C (O) alkenyl (C2-C6), C (O) - alkynyl (C2-C6), C (O) - [alkylene (C1-C6)] 0- 1-cycloalkyl (C3-C8), C (O) - [alkylene (C1-C6)] 0-1-heterocyclyl (C5-C10), or C (O) - [alkylene (C1-C6)] 0-1 - (C6-C10) aryl, R2 is H, (C1-C6) alkyl, [(C1-C6) alkylene] 0-1-R ', [(C1-C6) alkylene] 0-1-O-alkyl ( C1-C6), [(C1-C6) alkylene] 0-1-O-R ', [(C1-C6) alkylene] 0-1-NH2, [(C1-C6) alkylene] 0-1-NH- (C1-C6) alkyl, [(C1-C6) alkylene] 0-1-N [(C1-C6) alkyl] 2, [(C1-C6) alkylene] 0-1-CH [R '] 2, [ (C1-C6) alkylene] 0-1-C (O) -R ', [alkylene (C1-C6)] 0-1-C (O) NH2, [(C1-C6) alkylene] 0-1- C (O) NH-R ', or [(C1-C6) alkylene] 0-1-C (O) N [R'] 2; R3 is H, halogen, CN, (C1-C6) alkyl, (C1-C6) alkylene -R ', OH, O-R' ', NH2, NHR ", NR" R "or NH-C (O) - R '', R4 is H, halogen, hydroxy, CN, (C1-C6) alkyl, (C3-C8) cycloalkyl, (C1-C6) alkylene; R5 is H, halogen, CN, NO2, alkyl ( C1-C6), alkenyl (C2-C6), R ', alkylene (C1-C6) -aryl (C6-C10), alkenylene (C2-C6) - aryl (C6-C10), alkylene (C1-C6) - heterocyclyl (C5-C10), NH2, NH-R ', NH-SO2H, NH-SO2-alkyl (C1-C6), NH-SO2-R', NHC (O) -alkyl (C1-C6), NH- C (O) -R ', C (O) N [(C1-C6) alkyl] 2, C (O) OH or C (O) O-C1 (C6) alkyl; R6 and R6' are independently of each other H, R ', (C1-C8) alkyl, (C1-C6) -R' alkylene, (C1-C6) alkylene -O-C1-C6 alkyl, (C1-C6) -O-R 'alkylene, (C1-C6) alkylene -CH [R '] 2, (C1-C6) alkylene -C (O) -R', (C1-C6) alkylene -C (O) NH2, (C1-C6) alkylene (O) NH-R 'or (C1-C6) alkylene-C (O) N [R'] 2; R7 and R8 are independently from each other H, halogen, CN, NO2, (C1-C6) alkyl, O- (C1-C6) alkyl, O- [(C1-C6) alkylene] 0-1-R ', (C2-C6) alkenyl, R', (C2-C6) alkenylene-(C6-C10) alkylene, ( C1-C6) -R ' , NH2, NH-R ', NH-SO2H, NH-SO2-alkyl (C1-C6), NH-SO2-R', SO2-NH2, SO2-NHR ', NH-C (O) -alkyl (C1- C6), NH-C (O) -R ', C (O) N [(C1-C6) alkyl] 2, C (O) OH or C (O) O-C1-C6 alkyl; R9 is halogen or (C1-C6) alkyl; n is 0, 1, 2, 3 or 4; and L is O or O-alkylene (C1-C6); where R 'is cycloalkyl (C3-C8), heterocyclyl (C5-C10) or aryl (C6-C10); and R '' is (C3-C8) cycloalkyl, (C5-C10) heterocyclyl, (C6-C10) aryl, (C1-C6) alkyl, (C1-C6) -R 'alkylene, (C1-C6) alkylene - (C1-C6) alkyl, (C1-C6) -OR 'alkylene or (C1-C6) -NRxRy alkylene; and where Rx and Ry are independently from each other (C1-C6) alkyl, heterocyclyl (C5-C10), aryl (C6-C10), alkylene (C1-C4) -heterocyclyl (C5-C10), alkylene (C1-C4) - (C6-C10) aryl, (C1-C4) alkylene -NH-(C1-C6) alkyl, (C1-C4) alkylene - N [(C1-C6) alkyl] 2, (C1-C4) alkylene [(C6-C10) aryl] 2, or (C1-C4) alkylene -N [heterocyclyl (C5-C10)] 2; and where in the residues R4, R5, R7 and R8 a hydrogen atom of the alkyl or alkylene group may be optionally substituted with OH, OCH3, COOH, COOCH3, NH2, NHCH3, N (CH3) 2, CONH2, CONHCH3 or CON ( CH3) 2 or an alkyl or alkylene group may be halogenated one or more times; and wherein a cycloalkyl (C3-C8) group may contain 1 or 2 double bonds and the aryl (C6-C10) and heterocyclyl (C5-C10) groups are unsubstituted or substituted one or more times with suitable groups independently selected from halogen , CF3, NO2, N3, CN, C (O) -alkyl (C1-C6), C (O) -aryl (C6-C10), COOH, COOalkyl (C1-C6), CONH2, CONH-alkyl (C1- C6), WITH [(C1-C6) alkyl] 2, (C3-C8) cycloalkyl, (C1-C6) alkyl, (C1-C6) alkylene -OH, (C1-C6) -NH2 alkylene, (C1-) alkylene C6) -NH-(C1-C6) alkyl, (C1-C6) alkylene -N [(C1-C6) alkyl] 2, (C2-C6) alkenyl, (C2-C6) alkynyl, O (C1-) alkyl C6), OC (O) -alkyl (C1-C6), OC (O) -aryl (C6-C10), OC (O) -heterocyclyl (C5-C10), PO3H2, SO3H, SO2-NH2, SO2NH-alkyl (C1-C6), SO2N [(C1-C6) alkyl] 2, S-(C1-C6) alkyl; S-C 1 -C 6 alkaryl (C 6 -C 10) aryl, S-C 1 -C 6 alkyl-heterocyclyl (C 5 -C 10), SO (C 1 -C 6) alkyl, SO-C 1 -C 6 alkylene - (C6- C10) aryl, SO- (C1-C6) -heterocyclyl (C5-C10), SO2-C1-C6-alkyl, SO2-alkylene (C1-C6) -aryl (C6-C10), SO2- (C1-C6) alkylene e-heterocyclyl (C5-C10), SO2-NH-alkylene (C1-C6) -aryl (C1-C10), SO2-NH-alkylene (C1-C6) -heterocyclyl (C5-C10) , SO2-N [(C1-C6) alkyl] [alkylene (C1-C6) -aryl (C6-C10)], SO2-N [alkyl (C1-C6)] [alkylene (C1-C6) - heterocyclyl (C5 -C10)], SO2-N [alkylene (C1-C6) -aryl (C6-C10)] 2, SO2-N [alkylene (C1-C6) -heterocyclyl (C5-C10)] 2, C (NH) ( NH2), NH2, NH-(C1-C6) alkyl, N [(C1-C6) alkyl] 2, NH-C (O) -alkyl (C1-C6), NH-C (O) O-alkyl (C1 -C6), NHC (O) -aryl (C6-C10), NH-C (O) -heterocyclyl (C5-C10), NH-C (O) O-aryl (C6-C10), NH-C (O ) O-heterocyclyl (C5-C10), NH-C (O) - NH-alkyl (C1-C6), NH-C (O) -NH-aryl (C6-C10), NH-C (O) -NH -heterocyclyl (C5-C10), NH-SO2-alkyl (C1-C6), NH-SO2-aryl (C6-C10), NH-SO2- heterocyclyl (C5-C10), N-alkyl (C1-C6) - C (O) -C1-C6 alkyl, N-C1-C6 alkyl-C ( O) O-C1-C6 alkyl, N-C1-C6 alkyl-C (O) -aryl (C6-C10), N-C1-C6 alkyl-heterocyclyl-C (O), N- (C1-C6) alkyl-C (O) O-aryl (C6-C10), N-alkyl (C1-C6) -C (O) O-heterocyclyl (C5-C10), N-alkyl (C1-C6) -C (O) -NH-(C1-C6) alkyl, N-(C1-C6) alkyl-C (O) -NH-aryl (C6-C10), N-(C1-C6) -C (O) - NH- (C5-C10) heterocyclyl, N [C1-C6 alkyl] -C (O) -N [C1-C6 alkyl] 2, N [C1-C6 alkyl] -C (O) - N [(C1-C6) alkyl] - aryl (C6-C10), N [alkyl (C1-C6)] - C (O) -N [alkyl (C1-C6)] - heterocyclyl (C5-C10), N [(C1-C6) alkyl] - C (O) - N [aryl (C6-C10)] 2, N [(C1-C6) alkyl] - C (O) -N [heterocyclyl (C5-C10)] 2 , N [aryl (C6-C10)] - C (O) -alkyl (C1-C6), N [heterocyclyl (C5-C10)] - C (O) -alkyl (C1-C6), N [aryl (C6 -C10)] - C (O) O-(C1-C6) alkyl, N [heterocyclyl (C5-C10)] - C (O) Oalkyl (C1-C6), N (aryl) -C (O) -aryl (C6-C10), N [heterocyclyl (C5-C10)] - C (O) -aryl (C6-C10), N [aryl (C6-C10)] - C (O) O-aryl (C6-C10) , N [heterocyclyl (C5-C10)] - C (O) O-aryl (C6-C10), N [aryl (C6-C10)] - C (O) -NH-alkyl (C1-C6), N [ (C5-C10) heterocyclyl] - C (O) -NH-(C1-C6) alkyl, N (aryl) -C (O) -NH-aryl (C 6-C10), N [heterocyclyl (C5-C10)] - C (O) -NH-aryl (C6-C10), N [aryl (C6-C10)] - C (O) -N [C1- alkyl C6)] 2, N [heterocyclyl (C5-C10)] - C (O) -N [(C1-C6) alkyl] 2, N [aryl (C6-C10)] - C (O) -N [alkyl ( C1-C6)] - aryl (C6-C10), N [heterocyclyl (C5-C10)] - C (O) -N [alkyl (C1-C6)] - aryl (C6-C10), N [aryl (C6 -C10) l] -C (O) -N [aryl (C6-C10)] 2, N [heterocyclyl (C5-C10)] - C (O) -N [aryl (C6-C10)] 2, aryl ( C6-C10), alkylene (C1-C6) -aryl (C6-C10), O-alkylene (C1-C6) -aryl (C6-C10), heterocyclyl (C5-C10), alkylene (C1-C6) -heterocyclyl (C5-C10), O-alkylene (C1-C6) -heterocyclyl (C5-C10), wherein aryl (C6-C10) or heterocyclyl (C5-C10) can be substituted one to 3 times with halogen, OH, NO2, CN, (C1-C6) alkyl, (C1-C6) alkyl, NH2, NH (C1-C6) alkyl, N [(C1-C6) alkyl] 2, SO2CH3, COOH, C (O) O-C1-C6 alkyl, CONH2, C1-C6 alkylene-O-C1-C6 alkyl, C1-C6 alkyl-O-aryl (C6-C10), O-C1-C6 alkylene ) -aryl (C6-C10); or wherein aryl (C6-C10) is substituted neighborhoodly with an O-alkylene (C1-C4) -O group by which a 5-8-membered ring is formed together with the carbon atoms to which the atoms are attached of oxygen and wherein the aryl or heterocyclyl substituents of the aryl (C6-C10) and heterocyclyl (C5-C10) groups may not be further substituted with an aryl or heterocyclyl-containing group; or its pharmaceutically acceptable salts and / or its stereoisomeric forms. |
| priorityDate | 2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 331.