http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2371626-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_046993fcfc8440811f39622cc50d07c8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 |
| filingDate | 2008-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_746b9fdb4b24a1290dd985da66335f31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30db6e70ca12cd272dcfaa02c9b4708f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3a84271a1aa50452c26ffa502fd641d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5dfe8655d28e205825db1253f47eff7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83516c6a3b96024c08278365699645b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66078f76a837a4063e9c5538ed21a907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4559f651de44d81bf5107ac1982139d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d6ca5010beaebf91b36c9e32bc270c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6654677168dec0ef1ddd12a6c33c6c36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_647a7a55ca05a87a953c64ca5eb0cb59 |
| publicationDate | 2012-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2371626-T3 |
| titleOfInvention | DERIVATIVES OF HETEROARILPIPERIDINA SUBSTITUTED AS MODULATORS OF THE RECEIVER 4 OF THE MELANOCORTINA. |
| abstract | Compound according to formula (I) and enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof, wherein R1 is -N (R10) - (C (R6) 2) mT - (C (R6) 2 ) lT or -O- (C (R6) 2) mT; R6 is independently selected from C1-6 alkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN, OH and OCH3, and C3-6 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN, OH and OCH3; T is NR7R8, R7 and R8 are independently selected from each other of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C2-6-O-C1-6 alkyl, wherein each alkyl, alkenyl and alkynyl is optionally substituted with one or more halogen atoms, CN or OH; R9 is independently selected from halogen, CN, OH, C1-6 alkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN and OH, and O-C1-6 alkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN and OH, C1-6-O-C1-6 alkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN and OH, or NR12R13; R10 is H or C1-6 alkyl; R11 is independently selected from halogen, CN, OH, C1-6 alkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN and OH, C2-6 alkenyl, C2-6 alkynyl, O-C1-6 alkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN and OH, C1-6-O-C1-6 alkyl, optionally substituted with 1 to 3 substituents selected from halogen, CN and OH, C0-6 alkyl-C3 cycloalkyl -6, -OC (O) -C 1-6 alkyl, -NH 2, -NH (C 1-6 alkyl) and -N (C 1-6 alkyl) 2; R12 and R13 are independently selected from each other of C1-6 alkyl, optionally substituted with OH, C2-6 alkenyl, C2-6 alkynyl, C2-6-O-C1-6 alkyl and C2-6-N- alkyl (alkyl C1-6) 2; W is CH, O or NR10; X is CH or N; Y is CH or N; Z is CH or N; A is a saturated, unsaturated or aromatic 3-7 membered ring containing 0-2 nitrogen atoms; B is CR2 or N; G is CR2 or N; D is CR2 or N; E is CR2 or N; with the proviso that one or two of the variables B, G, D and E must be N; R2 is independently selected from morpholine, optionally substituted with from 1 to 3 identical or different R14 substituents, saturated or partially unsaturated heterocycle, from 4 to 7 members, containing in the ring a nitrogen atom and optionally an additional heteroatom selected from O, N and S, the heterocycle being optionally substituted with 1 to 4 identical or different R11 substituents, or NR12R13; R14 is C1-6 alkyl, C1-6-O-C1-6 alkyl, C1-6-OH alkyl, C1-6-NH2 alkylene, C1-6-NH-C1-6 alkyl or C1-6 alkylene N (C1-6 alkyl) 2; R15 is H or C1-6 alkyl; I is 0, 1, 2, 3 or 4; m is 0, 1, 2, 3 or 4; or is 0, 1 or 2; p is 0, 1, 2, 3 or 4; r is 0, 1, 2, 3 or 4; s is 1 or 2, and t is 0 or 1. |
| priorityDate | 2007-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 472.