http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2371335-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 |
| filingDate | 2001-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ca09c359b00d414c2fdcea4027e209c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba026b8dea4c2ce28e4816d75de3a7da |
| publicationDate | 2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2371335-T3 |
| titleOfInvention | IDENTIFICATION AND MODIFICATION OF IMMUNODOMINANT EPITHOPES IN POLYPEPTIDES. |
| abstract | Method of modifying a therapeutic polypeptide, comprising: (a) identifying at least one immunodominant epitope in the polypeptide using an antibody or population of antibodies obtained from an untreated human or untreated animal or a population thereof, where the Polypeptide has an amino acid sequence identical to the native sequence of an endogenous polypeptide homologue in the same human or the same animal species or a biologically active fragment of the endogenous polypeptide, where the antibody or antibodies do not substantially inhibit a therapeutic activity of the polypeptide; and the immunodominant epitope is not located in a region of the polypeptide that provides a therapeutic activity of the polypeptide; and (b) modify the immunodominant epitope to reduce an immune response to the polypeptide while maintaining a substantial therapeutic activity of the polypeptide. |
| priorityDate | 2000-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 385.