http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2371191-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf8de36b670d924c98d9418de6133180 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-00 |
| filingDate | 2006-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80512df9e8ee53fe50733910778d3754 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38775670ae19117ce7eb9b31ca588adb |
| publicationDate | 2011-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2371191-T3 |
| titleOfInvention | CYTOTOXIC COMPOUNDS. |
| abstract | A compound of the formula in which X is selected from O, S and NR23, wherein NR23 is a group selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and acyl; Z is O; R1 is H, substituted or unsubstituted C1-6 alkyl, C (O) R8, or CO2R8; R1 '' is H, substituted or unsubstituted C1-6 alkyl, or C (O) R8; each R8 is a member independently selected from NR9R10 and OR9 and R9 and R10 are members independently selected from H, substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl; R2 is H, substituted or unsubstituted C1-6 alkyl, unsubstituted heteroalkyl, cyano, or alkoxy; R2 '' is H, substituted or unsubstituted C1-6 alkyl, or unsubstituted heteroalkyl; R3 is a member selected from the group consisting of SR11, NHR11 and OR11, in which R11 is a member selected from the group consisting of H, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, diphosphates, triphosphates , acyl, C (O) R12R13, C (O) OR12, C (O) NR12R13, P (O) (OR12) 2, C (O) CHR12R13, SR12 and SiR12R13R14, in which R12, R13 and R14 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl and substituted or unsubstituted aryl, or R12 and R13 together with the nitrogen or carbon atom to which they are attached are joined to form a substituted heterocycloalkyl ring system or unsubstituted having from 4 to 6 atoms; R6 is a single bond which is either present or absent and when present R6 and R7 join to form a cyclopropyl ring; and R7 is CH2-X1 or -CH2- joined in said cyclopropyl ring with R6, wherein X1 is an assignment group; R4, R4 '', R5 and R5 '' are independently selected members from the group consisting of H, substituted alkyl, unsubstituted alkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, unsubstituted heteroaryl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, halogen, NO2, NR15R16, NC (O) R15, OC (O) NR15R16, OC (O) OR15, C (O) R15, SR15, OR15, CR15 = NR16, and O (CH2) nNR24R2525, where n is an integer from 1 to 20; R15 and R16 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl and substituted or unsubstituted peptidyl, in which R15 and R16 together with the nitrogen atom to which they are attached are optionally linked to form a substituted or unsubstituted heterocycloalkyl ring system having from 4 to 6 atoms, optionally containing two or more heteroatoms; and R24 and R25 are independently selected from hydrogen and unsubstituted alkyl, in which at least one of R24 and R25 is hydrogen, and in which at least one of R4, R4 '' '', R5 and R5 '' is O (CH2) nNR24R25. |
| priorityDate | 2005-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 207.