http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2370973-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2009-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6557fe015465995a1d15c689053df8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_798b19ad04ebd182a8bba526dd9ed6f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c165251812477c5f846c47c7304973a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfd0fb8acd03a1b755e91cc20224027f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_380f0c2123a1a216aa565951be3f3b46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b3e7344503a143cc35255511628d4e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_787efb25b8eb96ec30306d60929e2c7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab71138d3ef7f4b9ba541c00c1ef7564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85e6889a7703db04176bd12918bdf9a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76341038cffdb7eab7d6e41356bec366 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83a7246c161cc7884bc28742c67e3807 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_987137b55035b9734b4f61c5ddf3482a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_086c8ff15c48510c6c6cad8538472a26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9329cc276a7cd1d1633a2bb85f2a72b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09184f7c89b8d73d0003ca0bb2e9ef1e |
| publicationDate | 2011-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2370973-T3 |
| titleOfInvention | PIRROLOPIRAZINE QUINASE INHIBITORS. |
| abstract | A compound of the formula I ** Formula ** in which: R is R1, R2, R3 or R4; R1 is C1-C6 alkyl, C1-C6 alkoxy, phenyl, benzyl, heteroaryl, cycloalkyl, heterocycloalkyl or cycloalkylalkyl, optionally substituted by one or more R1a; R1a is R1b or R1c; R1b is halogen, oxo, hydroxy or -CN; R1c is -C (= O) O (R1f), -C (= O) CH2 (R1e), -S (R1f), -S (O) 2 (R1f) or -S (= O) (R1f), C1-C6 alkyl, C1-C6 alkoxy, amino, amido, C1-C6 haloalkyl, phenyl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkyloxy or heterocycloalkyloxy optionally substituted by one or more R1d; R1d is H, halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy or C1-C6 haloalkyl; R1e is H, C1-C6 alkyl, C1-C6 alkoxy, -CN, C1-C6 haloalkyl, phenyl, heteroaryl, cycloalkyl or heterocycloalkyl; R1f is H, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, heteroaryl, cycloalkyl or heterocycloalkyl; R2 is N (R2a) 2; each R2a is independently H or R2b; each R2b is independently C1-C6 alkyl, phenyl, heteroaryl, cycloalkyl, heterocycloalkyl or heterocycloalkyl-alkylene, optionally substituted by one or more R2c; R2c is R2d or R2e; R2d is halogen, oxo or hydroxy; R2e is -N (R2g) 2, -C (= O) (R2g), -C (= O) O (R2g), -C (= O) N (R2g) 2, -N (R2g) C (= O) (R2g), -S (= O) 2 (R2g), -S (O) 2N (R2g25) 2, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, phenyl, heteroaryl, heteroaryloxy, cycloalkyl or heterocycloalkyl, optionally substituted by one or more R2f; each R2f is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl; each R2g is independently H, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl or phenyl; R3 is -C (= O) R3a; R3a is C1-C6 alkyl, C1-C6 alkoxy, phenyl or N (R3b) 2; each R3b is independently H or C1-C6 alkyl; R4 is -O (R4a); R4a is H or R4b; R4b is C1-C6 alkyl, phenyl, benzyl, C1-C6 haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, optionally substituted by one or more R4c; R4c is halogen, hydroxy, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 alkoxy; Q2 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heteroaryl, optionally substituted by one or more Q2a; Q2a is Q2b or Q2c; Q2b is halogen, oxo, hydroxy, -CN, -SCH3, -S (O) 2CH3 or -S (= O) CH3; Q2c is Q2d or Q2e; or two Q2a together form a bicyclic ring system, optionally substituted by one or more Q2b or Q2c; Q2d is -O (Q2e), -S (= O) 2 (Q2e), -C (= O) N (Q2e) 2, -S (O) 2 (Q2e), -C (= O) (Q2e) , -C (= O) O (Q2e), -N (Q2e) 2; - N (Q2e) C (= O) (Q2e), -N (Q2e) C (= O) O (Q2e) or -N (Q2e) C (= O) N (Q2e) 2; each Q2e is independently H or Q2e ''; each Q2e '' is independently C1-C6 alkyl, phenyl, benzyl, C1-C6 haloalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heteroaryl, optionally substituted by one or more Q2f; Q2f is Q2g or Q2h; Q2g is halogen, hydroxy, cyano, oxo or -C (= O) (Q2h); Q2h is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, amino, phenyl, benzyl, cycloalkyl, heterocycloalkyl or heteroaryl, optionally substituted by one or more Q2i; and Q2i is halogen, hydroxy, cyano, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2008-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 935.