http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2370791-T3
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fda45c540f11df3a7fe71d54a70562a |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 |
filingDate | 2006-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2011-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff53a9f936d45dd328e88f629bec06e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05c33991f5107e7addf44305270b3c6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ccaff4cd2c656d79530a1e1817031d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca8c20c5e001b43a3043c37b0504b11d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f840ee298d4f70d95ead1a491cad7851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e520ac5f570244e0e49bf70656fa9db9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ceac7ec3a1162eb8c3458a589cef68a6 |
publicationDate | 2011-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2370791-T3 |
titleOfInvention | NEW THIOPHENE DERIVATIVES AS AGENISTS OF THE RECEPTOR OF SPHINGOSINE-1-PHOSPHATE-1. |
abstract | A compound selected from the group consisting of wn by thiophenes of Formula (I) ** Formula ** in which A represents -CH2CH2-, -CH = CH-, -NH-CH2-, -CH2-O-, or - CH2-NH-; R 1 represents hydrogen, C1-5 alkyl, C1-5 alkoxy, or halogen; R 2 represents hydrogen, C1-5 alkyl, C1-5 alkoxy, trifluoromethyl, trifluoromethoxy, or halogen; R 3 represents 2,3-dihydroxypropyl, -CH2- (CH2) k-NR 31 R 32, (azetidin-3-carboxylic acid) -1-yl-methyl, (alkyl 1-5 esters of azetidin-3-carboxylic acid) -1-yl-methyl, 2 - [(azetidin-3-carboxylic acid) -1-yl] -ethyl, 2 - [(alkyl1-5 azetidin-3-carboxylic acid ester) -1-yl] -ethyl, 3 - [(azetidin-3-carboxylic acid) -1-yl] -propyl, 3 - [(alkyl 1-5 esters of azetidin-3-carboxylic acid) -1-yl] -propyl, (pyrrolidin-3-carboxylic acid ) -1-yl-methyl, (alkyl 1-5 ester of pyrrolidin-3-carboxylic acid) -1yl-methyl, (pyrrolidin-2-carboxylic acid) -1-yl-methyl, (C1-5 alkyl ester of acid pyrrolidin-2-carboxylic) -1-yl-methyl, 2- [(pyrrolidin-3-carboxylic acid) -1-yl] -ethyl, 2 - [(alkyl 1-5 ester of pyrrolidin-3-carboxylic acid) - 1-yl] -ethyl, 2 - [(pyrrolidin-2-carboxylic acid) -1-yl] -ethyl, 2 - [(C1-5 alkyl ester of pyrrolidin-2-carboxylic acid) -1-yl] -ethyl , 3 - [(pyrrolidin-3-carboxylic acid) -1-yl] -propyl, 3 - [(alkyl 1-5 ester of pyrrolid acid in-3-carboxylic) -1-yl] -propyl, 3 - [(pyrrolidin-2-carboxylic acid) -1-yl] -propyl, 3 - [(C1-5 alkyl ester of pyrrolidin-2-carboxylic acid) -1-yl] -propyl, -CH2- (CH2) n-COOH, -CH2- (CH2) n-CONR 31 R 32, -CO-NHR 31, 1- (1- (3-carboxy-azetidinyl)) -2-acetyl, 1- (1- (2-carboxy-pyrrolidinyl)) -2-acetyl, 1- (1- (3-carboxy-pyrrolidinyl)) -2-acetyl, 1- (1- (3-carboxy-azetidinyl) )) - 3-propionyl, 1- (1- (2-carboxy-pyrrolidinyl)) - 3-propionyl, 1- (1- (3-carboxy-pyrrolidinyl)) - 3-propionyl, - (CH2) nCH (OH) - CH2-NR 31 R 32, 2-hydroxy-3-methoxy-propoxy, -OCH2- (CH2) m-NR 31 R 32, 2- pyrrolidin-1-yl-ethoxy, 3-pyrrolidin-1-yl-propoxy, 2-piperazin-1-yl-ethoxy, 2- [4- (C1-5 alkyl) -piperazin-1-yl] -ethoxy, 2- [4- (2- hydroxy-ethyl) -piperazin-1-yl] -ethoxy, 3-piperazin-1-yl-propoxy, 3- [4- (C1-5 alkyl) -piperazin-1-yl] -propoxy, 3- [4- (2-hydroxy-ethyl) piperazin-1- il] -propoxy, 2-morpholin-4-yl-ethoxy, 3-morpholin-4-yl-propoxy, 2 - [(azetidin-3-carboxylic acid) -1-yl] -ethoxy, 2- [(alkyl1- 5 azetidin-3-carboxylic acid ester) -1-yl] -ethoxy, 2 - [(pyrrolidin-3-carboxylic acid) -1-yl] -ethoxy, 2 - [(alkyl 1-5 ester of pyrrolidin-3-carboxylic acid) -1-yl] - ethoxy, 2 - [(pyrrolidin-2-carboxylic acid) -1-yl] -ethoxy, 2 - [(C1-5 alkyl ester of pyrrolidin-2-carboxylic acid) -1-yl] -ethoxy, 2 - [( 2-hydroxy-pyrrolidin) -1-yl] -ethoxy, 2 - [(3-hydroxy-pyrrolidin) -1-yl] -ethoxy, 3 - [(azetidin-3-carboxylic acid) -1-yl] -propoxy , 3 - [(alkyl1-5 azetidin-3-carboxylic acid) -1-yl] -propoxy acid, 3 - [(pyrrolidin-3-carboxylic acid) -1-yl] -propoxy, 3 - [(alkyl 1 -5 pyrrolidin-3-carboxylic acid) -1-yl] -propoxy, 3 - [(pyrrolidin-2-carboxylic acid) -1-yl] -propoxy, 3 - [(C1-5 alkyl pyrrolidin acid ester) -2-carboxylic) -1-yl] -propoxy, 3 - [(2-hydroxypyrrolidin) -1-yl] -propoxy, 3 - [(3-hydroxy-pyrrolidin) -1-yl] -propoxy, -O- CH2-CONR 31 R 32, 1- (1- (3-carboxy-azetidinyl)) - 1-oxo-2- ethoxy, 1- (1- (pyrrolidin-2-carboxylic acid) -1-yl) -1- oxo-2-ethoxy, 1- (1- (pyrrolidin-3-carboxylic acid) -1-yl) -1-oxo-2-ethoxy, 3- carbam oil-propoxy, 3- (C1-5carbamoyl) propoxy, 3- (2-hydroxyethylcarbamoyl) propoxy, -OCH2-CH (OH) -CH2-NR 31 R 32, 3 - [(azetidin-3-carboxylic acid) - 1-yl] -2-hydroxypropoxy, 3 - [(alkyl 1-5 ester of azetidin-3-carboxylic acid) -1-yl] -2hydroxypropoxy, 2-hydroxy-3 - [(pyrrolidin-3-carboxylic acid) -1 -yl] -propoxy, 2-hydroxy-3 - [(alkyl 1-5 ester of pyrrolidin-3-carboxylic acid) -1-yl] -propoxy, 2-hydroxy-3 - [(pyrrolidin-2-carboxylic acid) -1-yl] -propoxy, 2-hydroxy-3 - [(C1-5 alkyl pyrrolidin-2-carboxylic acid ester) -1-yl] -propoxy, 2-hydroxy-3 - [(2-hydroxy-pyrrolidin ) -1-yl] -propoxy, 2-hydroxy-3 - [(3-hydroxy-pyrrolidin) -1-yl] -propoxy, 2-hydroxy-3-pyrrolidin-1-yl-propoxy, 2-hydroxy-3 -piperazin-1-yl-propoxy, 2-hydroxy-3- [4- (C1-5 alkyl) piperazin-1-yl] -propoxy, 2-hydroxy-3- [4- (2-hydroxy-ethyl) - piperazin-1-yl] -propoxy, 2-hydroxy-3-morpholin-4-yl-propoxy, -NR 31 R 32, -NHCO-R 31, -CH2- (CH2) k-NHSO2R 33, - (CH2) nCH (OH) -CH2-NHSO2R 33, -OCH2- (CH2) m-NHSO2R 33, -OCH2-CH (OH) - CH2-NHSO 2R 33, -CH2- (CH2) k-NHCOR 34, - (CH2) nCH (OH) -CH2-NHCOR 34, -OCH2- (CH2) m-NHCOR 34, or -OCH2-CH (OH) - CH2- NHCOR 34; R 31 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, 2-hydroxyethyl, 2-hydroxy-1-hydroxymethyl-ethyl, 2-C1-5 alkoxyethyl, 3-hydroxypropyl, 3-C1-5 alkoxypropyl, 2-aminoethyl , 2- (C1-5 alkylamino) ethyl, 2- (di- (C1-5 alkyl) amino) ethyl, carboxymethyl, C1-5 carboxymethyl alkyl, 2-carboxy ethyl, or 2- (C1-5 carboxy alkyl) ethyl; R 32 represents hydrogen, methyl, or ethyl; R 33 represents methyl, ethyl, propyl, isopropyl, butyl, 2-hydroxyethyl, 2-methoxyethyl, methylamino, ethylamino, propylamino, isopropylamino, n-butylamino, or dimethylamino; R 34 represents hydroxymethyl, hydroxyethyl, aminomethyl, methylaminomethyl, dimethylaminomethyl, aminoethyl, 2-methylamino-ethyl, or 2-dimethylamino-ethyl; k represents the integer 1, 2, or 3; m represents the integer 1 or 2; n represents 0, 1, or 2; and R 4 represents hydrogen, C1-5 alkyl, methoxy or halogen; and configuration isomers such as optically pure enantiomers, mixtures of enantiomers such as racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, and mixtures of diastereomeric racemates, as well as salts and solvent complexes of said compounds, and morphological forms. |
priorityDate | 2005-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 425.