http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2369235-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132aa5ddba376cda52c2bedb26765245 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2005-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ac37ffbb6127e6e6a8ee7c2cdc27870 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_076599794ae6a5ac2ea3ae3b42e3b450 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85d70c7b13346030c441d23a48630886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6788bef72959735fc6f7bb210f3fe9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_499521783861e318c6491bd5d3cf4d75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6833a4b3c5f8ad1ddf290af9fff956b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dca457ced3ca46c8963adf31de992c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac7976e22a4e0d8a06a3e84d7ee60422 |
| publicationDate | 2011-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2369235-T3 |
| titleOfInvention | BENZOTIENE COMPOUNDS [2,3-D] PYRIMIDINE AS INHIBITORS OF THE ACTIVITIES OF THYROSINE KINASE OF THE RECEPTORS OF THE EPIDERMAL GROWTH FACTOR (EGFR) FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. |
| abstract | A compound of formula (I) in which m is 0, 1 or 2; R1 is selected from the group consisting of hydrogen, alkyl, and halo; R2 is selected from the group consisting of hydrogen, alkyl, and halo; and R3 is * -O (CH2) nAr, wherein Ar is phenyl, thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, pyridyl, pyrimidyl or pyridazinyl, in which Ar may be optionally substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, cyano, amino, methyl, ethyl, propyl, hydroxy, methoxy, ethoxy, propoxy, trifluoromethyl and trifluoromethoxy, and in which n is 0 or 1, or R2 and R3, together with the carbon atoms to which they are attached, form a pyrrole or pyrazole ring, said pyrrole or pyrazole ring being optionally substituted with 0, 1 or 2 substituents independently selected from the group consisting of alkyl, benzyl, halogenated benzyl, pyridylmethyl, pyridyl methoxy, and halogenated pyridylmethoxy; R4 is selected from the group consisting of hydrogen, methyl, ethyl, and halo; R5 is selected from the group consisting of hydrogen, methyl, and halo; R7 is selected from the group consisting of halo, hydroxy, alkyl, and alkenyl; or R7 is alkoxy, said alkoxy being optionally substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, alkoxy, alkoxycarbonyl, amino, alkylamino, morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, and alkylpiperazinyl, or R7 is alkylamino, said alkylamino being optionally substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, alkoxy, hydroxyalkylamino, alkoxyalkylamino, and morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, and alkylpiperazinyl, or R7 is alkyl selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl and t-butyl, said alkyl being substituted with 1, 2, 3 or 4 independently selected R7-1 substituents, in the that R7-1 is selected from the group consisting of halo, oxo, hydroxy, alkoxy, amino, hydroxycarbonyl, and alkoxycarbonyl, or R7-1 is alkylamino, and may be tar said alkylamino optionally substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, alkoxy, amino, alkylamino, alkylsulfonyl, pyrrolidinyl, morpholinyl, piperidinyl, and piperazinyl, or R7-1 is alkoxy, said alkoxy may be optionally substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, alkoxy, amino, alkoxycarbonyl, morpholinyl, pyrrolyl, and pyrrolidinyl, or R7-1 is a heterocycle selected from the group consisting of pyrrolidinyl, imidazolidinyl, imidazolyl, pyrazolyl, morpholinyl, piperidinyl, piperazinyl, and thiomorpholinyl, said heterocycle being optionally substituted with 0.1 or |
| priorityDate | 2004-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 358.