abstract |
A composition comprising a CD20 binding molecule, wherein said CD20 binding molecule has a binding affinity (Kd) for human CD20 of 5.0 x 10-10 M or less, and a dissociation rate (koff ) for human CD20 of 5.0 x 10 -4 s -1 or less, wherein said CD20 binding molecule is an antibody or antibody fragment comprising: a) a light chain variable region, wherein said variable light chain region comprises; i) an amino acid sequence of CDRL1 of SEQ ID NO: 5; ii) an amino acid sequence of CDRL2 of SEQ ID NO: 13; and iii) a CDRL3 amino acid sequence of SEQ ID NO: 19; and b) a heavy chain variable region, wherein said heavy chain variable region comprises; i) an amino acid sequence of CDRH1 of SEQ ID NO: 25; ii) an amino acid sequence of CDRH2 of SEQ ID NO: 39; and iii) a CDRH3 amino acid sequence of SEQ ID NO: 57. |