http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2368033-T3
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-06 |
| filingDate | 2000-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6b7f7e0abf8bf59064f239b4826837c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10042e04e383de840375858d938be03e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00f0b3f5ddbda874d7b6fc4d1708b839 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcc7d8c6c79dd745589ea8be345c5dc8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ce44fb695ca92b374e7cbbd9f022729 |
| publicationDate | 2011-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2368033-T3 |
| titleOfInvention | HISTONE DEACETILASE INHIBITORS. |
| abstract | A histone deacetylase inhibitor represented by the formula in which Cy-L 2 -Ar-Y 2 - (O) NH-Z Cy is cycloalkyl, aryl, heteroaryl, or heterocyclyl, any of which may be optionally substituted with one and four substituents selected from halo, hydroxy, nitro, haloalkyl, alkyl, alkaryl, aryl, aralkyl, alkoxy, aryloxy, amino, acylamino, alkylcarbamoyl, arylcarbamoyl, aminoalkyl, alkoxycarbonyl, carboxy, hydroxyalkyl, alkanesulfonyl, arenesulfonamido, alkanesulfonidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamidoamide , alkylcarbonyl, acyloxy, cyano and ureido, and wherein said aryl, heterocyclyl and heteroaryl may also be optionally substituted with one or more groups selected from (C1-C8) alkyl, di (C1-C6) amino, alkane alkane (C1-C6) acylamino and arene (C6-C10) acylamino, and wherein said cycloalkyl and heterocyclyl may also be optionally substituted with oxo, and wherein said heterocyclyl may be ta Also optionally independently substituted on nitrogen with a group selected from alkylsulfonyl, arylcarbonyl, arylsulfonyl and aralkoxycarbonyl, with the proviso that Cy is not a (spirocycloalkyl) heterocyclyl; L 2 is saturated C1-C8 alkylene or C2-C8 alkenylene, the alkylene or alkenylene may be optionally substituted with a group selected from oxo, halo, hydroxy, nitro, haloalkyl, alkyl, alkaryl, aryl, aralkyl, alkoxy, aryloxy, amino , acylamino, alkylcarbamoyl, arylcarbamoyl, aminoalkyl, alkoxycarbonyl, carboxy, hydroxyalkyl, alkanesulfonyl, arenesulfonyl, alkanesulfonamido, arenesulfonamido, aralkylsulfonamido, alkylcarbonyl, acyloxy, cyano and ureido on the condition that it is not in the condition of wherein one of the carbon atoms of the alkylene may optionally be replaced by a heteroatomic moiety selected from the group consisting of S; or S (O): o L 2 is S (O) 2- (CH2) 1-4: Ar is arylene, which arylene may optionally be fused with an aryl or heteroaryl ring, or with a saturated cycloalkyl or heterocyclic ring or unsaturated; and Y 2 is a saturated straight or branched chain alkylene; and Z is selected from the group consisting of anilinyl, pyridyl, thiadiazolyl, and -O-M, being M H or a pharmaceutically acceptable cation, thiadiazolyl may be optionally substituted with a substituent selected from the group consisting of thiol, trifluoromethyl, amino and sulfonamido; with the proviso that when the carbon atom to which Cy is attached is substituted with oxo, then Cy and Z are not both pyridyl. |
| priorityDate | 1999-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 256.