http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2367699-T3

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filingDate 2005-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2011-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc12727826a5f3a80b8b369c55c9360d
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publicationDate 2011-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2367699-T3
titleOfInvention DERIVATIVES OF DIHYDROPIRIDINONE.
abstract Compounds of general formula (I) ** Formula ** in which A represents an aryl or heteroaryl ring, R1, R3, independently of each other, represents hydrogen, halogen, cyano nitro, trifluoromethyl, C1-C6 alkyl, hydroxy, alkoxy C1-C6 or trifluoromethoxy, wherein C1-C6 alkyl and C1-C6 alkoxy may be further substituted with one to three identical or different radicals, selected from the group consisting of hydroxy and C1-C4 alkoxy, R6 represents - a formula group that can be substituted with up to two radicals independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, hydroxycarbonyl, C1-C6 alkoxy carbonyl and phenoxy, which in turn can be further substituted with halogen or trifluoromethyl, - a group of formula that are substituted with one or two radicals independently selected from the group consisting of C1-C6 alkyl, hydroxy, C1-C6 alkoxy, hydroxycarbonyl, C1-C6 alkoxy carbonyl, C1-C6 alkoxy carbonylamino, oxo, N-C1-C6 alkyl imino, N-C1-C6 imino alkoxy, benzyl and 5-6 membered heterocyclyl, which in turn can be further substituted with C1-C4 alkyl, - a group of formula in the that Z represents CH2 or N-R6A, where R6A represents hydrogen, C1-C6 alkyl, C1-C6 alkylcarbonyl or C1-C6 alkoxycarbonyl, - a group of formula in which R6B is selected from the group consisting of * 5 to 6 membered phenyl or heteroaryl, each of which may be additionally substituted with up to three radicals independently selected from the group consisting of halogen, trifluoromethyl, nitro, cyano, C1-C6 alkyl, hydroxycarbonyl, C1-C6 alkoxy carbonyl and C 1 -C 6 alkylcarbonyl, * C 3 -C 8 cycloalkyl * C 1 -C 6 alkyl which is substituted with hydroxy, C 1 -C 6 alkoxy, di-C 1 -C 6 alkylamino, hydroxycarbonyl, C 1 -C 6 alkoxy carbonyl, 5-6 heterocyclyl members or with 5-6 membered heteroaryl or phenyl, which in turn may be substituted additionally occasionally with up to three radicals independently selected from the group consisting of C1-C4 alkyl, halogen and hydroxycarbonyl, * 5-6 membered heteroarylcarbonyl and * C1-C6 alkoxycarbonyl, - a group of formula - a group of formula in which R6C represents hydrogen or C1-C4 alkyl, and R6D represents hydrogen or halogen, - a group of formula in which n represents an integer of 1 or 2, - mono- or di-C1-C6 alkylcarbonyl, in which the alkyl moiety or at least one alkyl moiety, respectively, is substituted with 5 to 6 membered * phenyl or heteroaryl, each of which is additionally substituted with one, two or three radicals independently selected from the group consisting of halogen, nitro , cyano, trifluoromethyl, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, trifluoromethoxy, di-C1-C4 alkyl, hydroxycarbonyl and C1-C4 alkoxycarbonyl, * C1-C6 alkoxy which is further substituted with hydroxy, C1- alkoxy C4, di-C1-C4 alkyl ino, C1-C4 alkoxy carbonyl or hydroxycarbonyl, * phenoxy * N-C1-C4-N-phenylamino * C3-C8 cycloalkyl * cyano or with * a group of formula in which R6E represents C1-C6 alkyl, C1- alkyl C6 carbonyl, C1-C6 alkoxy carbonyl or phenyl, which in turn may be additionally substituted with halogen, C1-C4 alkyl or C1-C4 alkoxy, - N-C1-C6-N-C3-C8 cycloalkyl aminocarbonyl, in the that the alkyl moiety may be further substituted with phenyl, 5-6 membered heteroaryl, hydroxycarbonyl or C1-C6 alkoxycarbonyl, -arylaminocarbonyl, wherein the aryl moiety is further substituted with one, two or three radicals independently selected from the group consisting of trifluoromethyl and C1-C4 alkyl, - N-C1-C6-N-arylaminocarbonyl alkyl, wherein the aryl moiety is substituted with one, two or three radicals independently selected from the group consisting of C1-C4 alkyl and halogen, and / or in which the alkyl moiety is substituted with fen ilo, or - a group of formula in which R6F represents hydrogen, C1-C6 alkyl, C1-C6 alkylcarbonyl or C1-C6 alkoxycarbonyl, and their salts, hydrates and / or solvates, and their tautomeric forms.
priorityDate 2004-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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