http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2367663-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9d046ec027ad7e0ef2127462eabaa99 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 2006-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83da59da82eae03c980853fb77a4b92c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd412a34928c5ec21276011db1593362 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d5c9992a45efcfea21b0ce19c750f33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7e6b0ff0d09476468adf69a8bffedd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d59644678500b575fd940c4a9545024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65ba2e6cdae54e121999248e8e314238 |
| publicationDate | 2011-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2367663-T3 |
| titleOfInvention | PHENYL DERIVATIVES - {3- (3- (1H-PIRROL-2-IL) - [1,2,4] OXADIAZOL-5-IL} PIPERIDIN-1-IL) -METANONE AND RELATED COMPOUNDS AS POSITIVE ALOSTERIC MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTORS. |
| abstract | A compound having the formula IB ** Formula ** Where R1 and R2 independently represent hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, arylalkyl, heteroarylalkyl, hydroxy, amino, aminoalkyl, hydroxyalkyl, C1- alkoxy C6 or R1 and R2 can together form a C3-C7 cycloalkyl ring, a C = O carbonyl bond or a carbon double bond; P represents a C5-C7 heterocycloalkyl ring, C5-C7 heterocycloalkenyl or a heteroaryl group of formula ** Formula ** R3, R4, R5, R6, and R7 are independently hydrogen, halogen, -NO2, C1-C6 alkyl substituents, C3-C6 cycloalkyl, C3-C7 cycloalkylalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, heteroaryl, heteroaxylalkyl, arylalkyl, aryl, -OR8, -NR8R9, -C (= NR10) NR8R9, -NR8C9, -NR8C9, -NR8C9 NR8CO2R9, NR8SO2R9, NR10CO NR8R9, -SR8, -S (= O) R8, -S (= O) 2R8, -S (= O) 2NR8R9, -C (= O) R8, -C (O) -O- R8, -C (= O) NR8R9, C (= NR8) R9, or C (= NOR8) R9; where optionally two substituents combine with the intermediate atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring; where each ring is optionally further substituted with 1 to 5 halogen groups, -CN, C1-C6 alkyl, -O-C0-C6 alkyl, -C3-C7 alkylcycloalkylalkyl, -O (aryl), - O (heteroaryl), -O -C1-C3 alkyl aryl, -O-C1-C3 alkyl heteroaryl, -N (C0-C6 alkyl) (C1-C3 alkyl) aryl) or -N (C0-C6 alkyl) (C1 alkyl) -C3) heteroaryl) independent; R8, R9, R10 are each independently hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, cycloalkyl (C3C7) alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl; each of which is optionally substituted with 1 to 5 independent halogen substituents, -CN, C1-C6 alkyl, -O-C0-C6 alkyl, -O-C3-C7 cycloalkylalkyl, -O (aryl), -O (heteroaryl ), N (C0-C6-alkyl) 2, -N (C0-C6 alkyl) (C3-C7 cycloalkyl) or N (C0-C6 alkyl) (aryl); D, E, F, G, K and L in P independently represent -C (R3) =, -C (R3) = C (R4) -, -C (= O) -, -C (= S) -, -O-, -N =, N (R3) - or -S-; Q indicates a C5-30-C6 cycloalkyl, aryl or heteroaryl group of formula ** Formula ** R3, R4, R5, R6, and R7 are independently defined as before; D, E, F, G and H in Q independently represent -C (R3) =, -C (R3) = C (R4) -, -C (= O) -, -C (= S) -, -O -, -N =, N (R3) - or -S-; V1, V2 and V4 independently represent -O- or -N = and V3 is C or V1, V2 and V4 represent -N = and V3 is -N-; B represents a single bond, -C (= O) -C0-C2 alkyl, -C (= O) -C2-C6 alkenyl, -C (= O) -C2-C6 alkynyl, -C (= O) O- , C (= O) NR8-C0-C2 alkyl, -C (= NR8) NR9, -S (= O) -C0-C2 alkyl, -S (= O) 2-C0-C2 alkyl, -S (= O) 2NR8-C0-C2 alkyl, C (= NR8) -C0-C2 alkyl, -C (= NOR8) -C0-C2 alkyl or -C (= NOR8) NR9-C0-C2 alkyl; R8 and R9, are defined independently as before; J represents -C (R10, R11), -O-, -N (R10) - or -S-; R10, R11 are independently hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C3-C7 cycloalkylalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl alkyl; each of which is optionally substituted with 1 to 5 halogen substituents, -CN, - (C1-C6) alkyl -O-C05 alkyl C6, -O-cycloalkyl (C3-C7) alkyl, -O (aryl), - O (heteroaryl), -N (C0-C6 alkyl) (C0-C6 alkyl), -N (C0C6 alkyl) (C3-C7 cycloalkyl) or N (C0-C6 alkyl) (aryl) independent; Any N can be an N-oxide; or pharmaceutically acceptable salts, hydrates or solvates of such compounds. |
| priorityDate | 2005-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 649.