| abstract |
An isolated monoclonal antibody or antigen binding portion thereof, which specifically binds and neutralizes Clostridium difficile toxin A (C. difficile), wherein the antibody, or antigen binding portion thereof, comprises: (a ) a variable heavy chain region comprising the amino acid sequences of CDR1, CDR2 and CDR3 of SEQ ID NO: 7 to 9 and a variable light chain region comprising the sequences of CDR1, CDR2 and CDR3 of SEQ ID NO. : 16 to 18; (b) a region of the variable heavy chain comprising the amino acid sequences of CDR1, CDR2 and CDR3 of SEQ ID NO: 10 to 12 and a region of the variable light chain comprising the sequences of CDR1, CDR2 and CDR3 of SEC ID No.: 19 to 21; or (c) a region of the variable heavy chain comprising the amino acid sequences of CDR1, CDR2 and CDR3 of SEQ ID NO: 13 to 15 and a region of the variable light chain comprising the sequences of CDR1, CDR2 and CDR3 of SEQ ID NO: 22 to 24. |