http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2366199-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3120ae9cab5bb4831f0cc16288966367 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 |
| filingDate | 2000-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46df95a868943f4b942fd23531a26c93 |
| publicationDate | 2011-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2366199-T3 |
| titleOfInvention | SEPARATION OF GLP-1 AND PEPTIDES ASSOCIATED BY ION EXCHANGE CHROMATOGRAPHY. |
| abstract | Cation exchange chromatography process for the purification of a GLP-1 peptide from a mixture comprising said GLP-1 peptide and related impurities, comprising the step of: separating said GLP-1 peptide and said related impurities from said mixture by elution in a solution consisting essentially of an organic modifier, water, optionally a salt component, and optionally a buffer, with a linear or stepped gradient or isocratically in a salt component and / or with a linear or stepped pH gradient or at a constant pH value, where the gradient of the pH or the pH value should be in the range where said GLP-1 peptide has a net global or positive local charge different from the positive local or global network of said related impurities to remove said related impurities; where the organic modifier is selected from C1-6 alkanol and C2-6 glycol; and where the related impurities are impurities that have a global or different local net charge and are selected from the group consisting of truncated forms, extended forms, forms with extra amino acids, derivatives, esters, deamidated forms, incorrectly folded forms, forms with undesired glycosylation and forms with sialylation. |
| priorityDate | 1999-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 170.