| abstract |
A compound having Formula (I) ** Formula ** or a stereochemically isomeric form thereof, wherein R 1 is C 1-6 alkyl; or C1-3 alkyl substituted with C3-7 cycloalkyl, phenyl, or phenyl substituted with halo, trifluoromethyl or trifluoromethoxy; R2 is halo, trifluoromethyl, C1-3alkyl or cyclopropyl; R3 is hydrogen or halo; X is O, S, SO, SO2 or CF2; and Ar is unsubstituted phenyl; unsubstituted pyridinyl; or phenyl or pyridinyl substituted with one or two substituents selected from the group consisting of halo, C1-3 alkyl, C1-3 alkoxy, trifluoromethyl, hydroxy-C1-3 alkyl and (CH2) n CO2H, in which n = 0, 1 or 2; or a pharmaceutically acceptable salt or solvate thereof, provided that, when R3 is 2'-fluoro, Ar is not then 3-pyridinyl substituted with one or two C1-3 alkyl substituents. |