http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2364864-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd3ed6a416dee19f896860de1125ce3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4bab626e01a18bba25c43aa9dbf7384 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_314b67bf53269592ef6568d132e59492 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0547e04211584b4dff03d69684255018 |
| publicationDate | 2011-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2364864-T3 |
| titleOfInvention | ACILAMINOPIRAZOLES AS FGFR INHIBITORS. |
| abstract | A compound of formula (I): ** (See formula) ** or a pharmaceutically acceptable salt thereof. wherein ring A represents a 5 or 6 membered aromatic group optionally comprising at least one ring heteroatom selected from nitrogen, oxygen and sulfur; Ring B represents a 5 or 6 membered aromatic group optionally comprising at least one ring heteroatom selected from nitrogen, oxygen and sulfur; each R1 independently represents a halogen, a hydroxyl group, a cyano group, a C1-C3 alkyl group optionally substituted with one or more substituents selected from C1-C3 alkoxy, C3 cycloalkyl, C1-C3 alkylthio, -NR4R5 (each which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl, a C3-5 cycloalkyl group optionally substituted with one or more substituents selected from C1-C3 alkyl, C1-C3 alkoxy, C3 cycloalkyl, C1-C3 alkylthio, -NR6R7 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl, a group C2-C3 alkenyl optionally substituted with one om are substituents selected from C1-C3 alkoxy, C3 cycloalkyl, C1-C3 alkylthio, -NR8R9 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1 alkylthio -C3, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxy and trifluoromethyl), halogen and hydroxyl, a phenyl group optionally substituted with one or more substituents selected from C1-C3 alkoxy, C3 cycloalkyl, C1 alkylthio -C3, -NR10R11 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di- C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl, a 4- to 6-membered heterocyclyl group optionally substituted with one or more substituents selected from C1-C3 alkyl, C1-C3 alkoxy, C3 cycloalkyl, C1-C3 alkylthio, - NR12R13 (each of which may be optionalm entity substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl , a C1-C3 alkoxy group optionally substituted with one or more substituents selected from C1-C3 alkoxy, C3 cycloalkyl, -NR14R15 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxy and trifluoromethyl), halogen and hydroxyl, a group -NR16R17, a group -OCOR18, a group -CO2R19, a group -CONR20R21, a group -NR22COR23, a group -NR24CO2R25. a group -OSO2R26, or two adjacent R1 groups together with the atoms to which they are attached form a 4- to 7-membered carbocyclyl or heterocyclyl ring optionally substituted with one or more substituents selected from C1-C3 alkyl, C1-C3 alkoxy, cycloalkyl C3, C1-C3 alkylthio, -NR27R28 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono - and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl; each R2 independently represents a hydroxyl group, a halogen, a cyano group, a group -CO2R29, a group -CONR30R31, a group -NR32COR33, a group -NR34CO2R35, a group -NR36R37, a group -SO2R38, a group -SO2NR39R40, a group -NR41SO2R42, a C1-C6 alkyl group optionally substituted with one or more substituents selected from C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkylthio, -NR43R44 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, C3-C6 cycloalkyl, amino (-NH2), mono- and di-C1-C3 alkylamino, cyano, hydroxyl, trifluoromethyl and a group 4 to 7-membered heterocyclyl optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, C3-C6 cycloalkyl, amino (-NH2), mono- and di-C1-alkylamino -C3, cyano, hydroxyl, trifluoromethyl), halogen, hydroxyl, and a heterocyclyl group of 4 to 7 members optionally condensed with a 4- to 7-membered carbocyclyl or heterocyclyl group optionally substituted with one or more substituents selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkylthio -NR45R46, -CO2R47 ( each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), cyano, halogen and hydroxyl, a C3-C6 cycloalkyl group optionally substituted with one or more substituents selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkylthio, -NR48R49 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl ), halogen, hydroxyl, and a heterocyclyl group of 4 to 7 m seeds optionally substituted with one or more substituents selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkylthio, -NR50R51 (each of which may be optionally substituted with one or more substituents selected from halogen , C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl, a C2-C6 alkenyl group optionally substituted with one or more substituents selected from C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkylthio, -NR52R53 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1- alkoxy C3, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen, hydroxy, and a 4- to 7-membered heterocyclyl group optionally substituted with one or more substituents selected from C1-C6 alkyl, C1-C6 alkoxy, cycloalkyl or C3-C6, C1-C6 alkylthio, -NR54R55 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2 ), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl, a 4- to 7-membered heterocyclyl group optionally condensed with a 4- to 7-membered carbocyclyl or heterocyclyl group and optionally substituted with one or more substituents selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkylcarbonyl, C3-C6 cycloalkyl, C1-C6 alkylthio, -NR56R57, SO2R58 (each of which may optionally be substituted with one or more substituents selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and C1-C3 dialkylamino, hydroxyl and trifluoromethyl), halogen, oxo, hydroxyl and a 4- to 7-membered heterocyclyl group optionally substituted with one or more of its substituents selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkylthio, -NR59R60, -SO2R61 (each of which may be optionally substituted with one or more substituents selected from halogen, C1- alkyl C3, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl, a C1-C6 alkoxy group optionally substituted with one or more substituents selected from C1-C6 alkoxy, C3-C6 cycloalkyl, -NR62R63 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, amino (-NH2), mono - and C1-C3 di-alkylamino, hydroxyl and trifluoromethyl), halogen, hydroxyl and a 4- to 7-membered heterocyclyl group optionally substituted with one or more substituents selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkylthio, -NR64R65 (each of which may be optionalm entity substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl , or two adjacent R2 groups together with the atoms to which they are attached form a 4- to 7-membered carbocyclyl or heterocyclyl ring optionally substituted with one or more substituents selected from C1-C3 alkyl, C1-C3 alkoxy, C3 cycloalkyl, C1 alkylthio -C3, -NR66R67 (each of which may be optionally substituted with one or more substituents selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di- C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl; R3 represents hydrogen, a C1-C3 alkyl group optionally substituted with one or more substituents selected from C1-C3 alkoxy, C3 cycloalkyl, C1-C3 alkylthio, -NR68R69 (each of which may be optionally substituted with one or more selected substituents between halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino (-NH2), mono- and di-C1-C3 alkylamino, hydroxyl and trifluoromethyl), halogen and hydroxyl, a is 0, 1, 2 , 3 or 4; b is 0, 1, 2, 3 or 4; each of R4 and R5 independently represents hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl, or |
| priorityDate | 2006-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1595.