| abstract |
A compound that is a Syk kinase inhibitor compound for use in the treatment of a proliferative cell disorder, wherein the compound is (a) N2- (2-methyl-1-benzo [d] imidazol-6-yl) - N4- (2,2-dimethyl-3 (4H) -oxo-2H-benzo [b] [1,4] thiazin-6-yl) -5-fluoro-2,4-pyrimidinadiamine (b) N2- (4-carbamoylphenyl ) -N4- [3-Chloro-4- (cyanomethoxy) phenyl] -5-fluoro-2,4-pyrimidinadiamine (c) N2- (3-chloro-4-methoxyphenyl) -5-fluoro-N4- (3- oxo-4H-5-pyrido [1,4] oxazin-6-yl) -2,4-pyrimidinadiamine (d) N4- (2,2-dimethyl-3-oxo-4H-5-pyrido [1,4] oxazin-6-yl) -5-fluoro-N2- (3,4,5-trimethoxyphenyl) -2,4-pyrimidinadiamine (e) (N4- (2,2-dimethyl-4 - [(dihydrogen-phosphonoxy) methyl ] -3-oxo-5-pyrido [1,4] oxazin-6-yl) -5-fluoro-N2- (3,4,5-trimethoxyphenyl) -2,4-pyrimidinadiamine) or a salt, hydrate, solvate , or N-oxide thereof. |