http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2364150-T3
Outgoing Links
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| filingDate | 2005-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d939b5fe5713c2c113fd11158097c5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb9c0c15b920a35c76a80ff506ba3622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a2b2f39d889002473da193a526b5ae1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1efe336f43a5eb17917618af093c0f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b851049312b6ca23f26f027a1a07065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_066cae394fd8410f14816dc399e825d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55d516544f06164b325d34199bc7c4fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4d85aac7873471dd1499a384a080dda |
| publicationDate | 2011-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2364150-T3 |
| titleOfInvention | DERIVATIVES OF BUTANOIC ACID, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR THERAPEUTIC APPLICATIONS. |
| abstract | Compound of formula (I): ** Formula ** in which: R is selected from a hydrogen atom and a C1-C10 alkyl radical; R1 and R2, which can be identical or different, are chosen such that: A.- or: R1 is chosen from: * an aryl radical (C6-C18) having between two and five identical G substituents or different, wherein G is selected from the trifluoromethyl group; styryl; a halogen atom; a monocyclic, bicyclic or tricyclic aromatic heterocyclic radical comprising one or more heteroatoms chosen from O, N and S, wherein the monocyclic heteroaryls are chosen from pyridine, imidazole, thiazole, isoxazole, isothiazole, furazone, pyridazine, pyrimidine, pyrazine , thiazine, oxazole, pyrazole, oxadiazole, triazole and thiadiazole, where the bicyclic heteroaryls are chosen from indolizine, isoindole, indazole, benzimidazole, benzothiazole, benzofurazane, benzothiofurazane, purine, quinoline, isoquinoline, cinolina, quinazine, phinalazine , pyrazolotriazine, pyrazolopyrimidine and pteridine, and wherein the tricyclic heteroaryls are chosen from acridine, phenazine and carbazole; and optionally substituted by one or more radicals T as defined below; a Het-CO- group, in which Het represents an aromatic heterocyclic radical as defined above optionally substituted by one or more T radicals; a C1-C6 alkylenediyl chain; a C1-C6 alkylenedioxy chain; nitro; cyano; (C1-C10) alkyl; (C1-C10) alkylcarbonyl; (C1-C10) alkoxycarbonyl-A-, in which A represents (C1-C6) alkylene, (C2-C6) alkenylene or a bond; (C3-C10) cycloalkyl; trifluoromethoxy; di (C1-C10) alkylamino; (C1-C10) (C1-C10) alkoxy; (C1-C10) alkoxy; (C6-C18) aryl optionally substituted by one or more radicals T; (C6-C18) aryl (C1-C10) alkoxy- (CO) n, in which n is 0 or 1 and the aryl is optionally substituted by one or more radicals T; (C6-C18) aryloxy (CO) n-, in which n is 0 or 1 and in which the aryl is optionally substituted by one or more radicals T; (C6-C18) arylthio, in which the aryl is optionally substituted by one or more radicals T; (C6-C18) aryloxy (C1-C10) alkyl (CO) n-, in which n is 0 or 1 and in which the aryl is optionally substituted by one or more radicals T; a saturated or unsaturated, monocyclic heterocycle with 5 to 8 members comprising one or more heteroatoms chosen from O, N and S, optionally substituted by one or more radicals T; (C6-C18) arylcarbonyl optionally substituted by one or more radicals T; (C6-C18) arylcarbonyl-B- (CO) n-, in which n is 0 or 1; B represents (C1-C6) alkylene or (C2-C6) alkenylene and the aryl is optionally substituted by one or more radicals T; (C6-C18) aryl-C- (CO) n-, in which n is 0 or 1, C represents (C1-C6) alkylene or (C2-C6) alkenylene and the aryl is optionally substituted by one or more radicals T; (C6-C18) fused aryl with a saturated or unsaturated heterocycle as defined above, optionally substituted by one or more radicals T; (C2-C10) alkynyl; wherein T is chosen from a halogen atom; (C6-C18) aryl; (C1-C6) alkyl; (C1-C6) alkoxy; (C1-C6) (C6-C18) alkoxy aryl; nitro; carboxyl; (C1-C6) alkoxycarboxyl; and T may represent oxo in the case where it replaces a saturated or unsaturated heterocycle; or T represents (C1-C6) alkoxycarbonyl (C1-C6) alkyl; or (C1-C6) alkylcarbonyl ((C1-C6) alkyl) n-, in which n is 0 or 1; * an (C6-C18) aryl radical having a substituent G, which comprises an optionally substituted (C6-C18) aryl radical or a saturated, unsaturated or aromatic monocyclic heterocyclic radical, with up to 8 optionally substituted members containing one or more heteroatoms chosen from O, N and S; * an optionally substituted (C6-C18) aryl radical, fused with a saturated or unsaturated polycyclic or monocyclic core with 5 to 8 members that optionally contains one or more heteroatoms chosen from oxygen and sulfur, said nucleus being optionally substituted; * an optionally substituted (C6-C18) aryl radical, fused with a saturated or unsaturated polycyclic or monocyclic nucleus with 6 to 8 members comprising at least one nitrogen atom as a heteroatom, said nucleus being the same optionally substituted; and * a saturated, unsaturated or aromatic monocyclic heterocyclic radical, optionally substituted with up to 8 members containing one or more heteroatoms chosen from oxygen, nitrogen and sulfur, wherein the aromatic heterocyclic groups are heteroaryls selected from the group of furan, thiophene, pyrrole, imidazole, thiazole, isoxazole, isothiazole, furazano, pyridazine, pyrimidine, pyrazine, thiazines, oxazole, pyrazole, oxadiazole, triazole and thiadiazole; and, in this case, R2 is chosen from: * a (C6-C18) aryl radical, which is optionally substituted and / or optionally fused with a saturated or unsaturated polycyclic or monocyclic core with 5 to 8 members that optionally contains one or more heteroatoms chosen from O, N and S, said nucleus being optionally substituted; and * a monocyclic aromatic heterocyclic radical optionally substituted with 5 to 8 members containing one or more heteroatoms chosen from O, N and S; B.- or: R2 is chosen from: * an (C6-C18) aryl radical substituted by a (C6-C18) aryl radical, which is optionally substituted and / or optionally fused with a saturated or unsaturated polycyclic or monocyclic nucleus with up to 8 members that optionally contain one or more heteroatoms chosen from O, N and S, said core being optionally substituted; and * a monocyclic aromatic heterocyclic radical optionally substituted with 5 to 8 members containing one or more heteroatoms chosen from O, N and S; and, in this case, R1 is chosen from: * an optionally substituted (C6-C18) aryl radical fused with a saturated or unsaturated polycyclic or monocyclic nucleus with 5 to 8 members that optionally contains one or more heteroatoms chosen from oxygen and sulfur, said core being the same optionally substituted; * an optionally substituted (C6-C18) aryl radical fused with a saturated or unsaturated polycyclic or monocyclic nucleus with 6 to 8 members having at least one nitrogen atom as a heteroatom, said nucleus being optionally substituted; and * a saturated, unsaturated or aromatic monocyclic heterocyclic radical, with up to 8 optionally substituted members containing one or more heteroatoms chosen from oxygen, nitrogen and sulfur, wherein the aromatic heterocyclic groups are heteroaryls selected from the group of furan, thiophene, pyrrole, imidazole, thiazole, isoxazole, isothiazole, furazano, pyridazine, pyrimidine, pyrazine, thiazines, oxazole, pyrazole, oxadiazole, triazole and thiadiazole; its optical isomers, and its pharmaceutically acceptable addition salts with acids or bases, with the R2 restriction that if it represents a phenyl radical not substituted by an aromatic or heteroaromatic radical, R1 cannot represent a phenyl radical that is substituted by a phenyl radical or naphthyl wherein the term "aryl radical" refers to a monocyclic or polycyclic carbocyclic aromatic radical. |
| priorityDate | 2004-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 328.