| abstract |
Compound of formula II (a): ** Formula ** or of formula II (b): ** Formula ** or of formula III (a): ** Formula ** or of formula III (b): ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, in which: X is CR4, CHR4, N, NR9, O or S; Y is CR4, CHR4, N, NR9, O or S; Z is CR4, CHR4, N, NR9, O or S; R1 is hydrogen or optionally substituted alkyl having between 1 and 4 carbon atoms; each R4 is independently OR4A, OC (O) R4A, hydrogen, halogen or alkyl, aryl, alkylaryl, arylalkyl, heteroalkyl, heterocycle, optionally substituted alkylheterocycle or heterocycloalkyl; R5 is OR5A, OC (O) R5A, hydrogen or halogen; R6 is OR6A, OC (O) R6A, hydrogen or halogen; R7 is OR7A, OC (O) R7A, hydrogen or halogen; R8 is CH2OR8A, CH2OC (O) R8A, hydrogen or halogen; each R9 is independently hydrogen or alkyl, aryl, alkylaryl, arylalkyl, heteroalkyl, heterocycle, alkylheterocycle or heterocycloalkyl optionally substituted; and each of R5A, R6A, R7A and R8A is, independently, hydrogen or optionally substituted alkyl. |