http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2362675-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5390cdfb70e9c5eb00596ee5b7f88720 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-96 |
| filingDate | 2006-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea9f9f3c0128c983b96c71f26b7788ea |
| publicationDate | 2011-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2362675-T3 |
| titleOfInvention | STABLE WATER SYSTEMS THAT INCLUDE PROTEINS. |
| abstract | A method for method of increasing the stability of a protein in an aqueous system, comprising: (a) selecting a pH for the composition that is within a range of protein stability that is at least 50% of the maximum stability of the protein with respect to pH; and (b) preparing a composition comprising the protein and two stabilizing agents, characterized in that: (i) the two stabilizing agents have ionizable groups capable of exchanging protons with the protein and with the ionized products of water dissociation; (ii) ionizable groups consist of first groups that are positively charged when protonated and uncharged when deprotonated, and second groups that are uncharged when protonated and negatively charged when deprotonated, in which the first and second groups have pKa values, respectively, of 1 to 5 higher pH units and 1 to 5 units lower than the pH of the composition; and (iii) the pH of the composition is within a range of stability of the protein that is at least 50% of the maximum stability of the protein with respect to the pH. |
| priorityDate | 2005-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 514.