http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2361783-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132aa5ddba376cda52c2bedb26765245 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
filingDate | 2007-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2011-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_481aeb989be6f349c8900c942f898f6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65c5c7c063dba00a936b7f0811e0888a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_602ff22a5154898c7188de9565ab1208 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e065490a7997289785a27b43d424f1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c85e5e2b61412a76be7a0909aeba3054 |
publicationDate | 2011-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2361783-T3 |
titleOfInvention | 3-CIANO-5-TIAZAHETEROARIL-DIHIDROPIRIDINAS AND ITS USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES. |
abstract | Compound of formula (I) ** Formula ** in which Ar represents (C6-C10) aryl or 5-10 membered heteroaryl with up to two ring heteroatoms of the N, O and / or S series, which may be substituted respectively one to three times, in the same or different manner, with substituents selected from the halogen, cyano, (C1-C4) alkyl, (C1-C4) alkoxy and (C1-C4) alkylthio, the alkyl moieties being substituted , alkoxy and alkylthio mentioned on their side with cyano or up to three times with fluorine, or Ar represents a group of formula in which * means the site of binding with the dihydropyridine ring, R5 means hydrogen or (C1-C4) alkyl, R6 means hydrogen, fluorine, chlorine, cyano, nitro, trifluoromethyl or (C1-C4) alkyl, and R7 means hydrogen or fluorine, R1 represents (C1-C6) alkyl, which may be substituted with phenyl, or represents (C1-) alkylthio C6), the alkyl and alkylthio moieties mentioned on their side may be substituted up to three times with n fluorine, R2 represents (C1-C6) alkyl, which may be substituted with cyano, hydroxyl, (C1-C4) alkoxy, trifluoromethoxy, amino, mono (C1-C4) -amino, di-(C1-C4) alkyl ) -amino, cycloalkyl (C3-C6), phenyl or up to three times with fluorine, or represents cycloalkyl (C3-C6), X represents N or C-R4, and R3 and R4 are the same or different and independently represent hydrogen , halogen, amino, mono (C1-C4) alkyl-amino or di (C1-C4) -amino, represent (C1-C4) alkyl, which may be substituted with hydroxyl, (C1-C4) alkoxy, amino , mono-C1-C4 alkyl-amino, di-C1-C4 alkyl-amino or up to three times with fluorine, or represents phenyl, which may be substituted with halogen, cyano, C1-C4 alkyl, trifluoromethyl , (C1-C4) alkoxy or trifluoromethoxy, R3 and R4, when the latter is present, are bonded together and form, together with the carbon atoms to which they are attached, a condensed 5 to 7 membered cycloalkyl ring, which may be substituted c on (C1-C4) alkyl or (C1-C4) alkoxy and in which a ring CH2 group may be exchanged for an O atom, or a condensed phenyl or pyridyl ring, which may be substituted respectively with halogen, cyano , (C1-C4) alkyl, trifluoromethyl, (C1-C4) alkoxy or trifluoromethoxy, as well as their salts, solvates and solvates of the salts. |
priorityDate | 2006-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1068.