| abstract |
Solid oral prolonged release dosage form comprising a prolonged release matrix formulation, the extended release matrix formulation comprising a composition comprising at least: (1) at least one polyethylene oxide which, according to rheological measurements, has a molecular weight approximately at least 1,000,000; and (2) at least one active agent selected from the members of the group consisting of opioid analgesics, wherein the opioid analgesic is oxycodone hydrochloride and the dosage form comprises from 5 mg to 500 mg of oxycodone hydrochloride; and wherein the composition comprises at least about 80% (by weight) of polyethylene oxide which, according to rheological measurements, has an approximate molecular weight of at least 1,000,000. |