http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2361338-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938a6d7a15cbc93a74abe1953eb25d47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 |
| filingDate | 2006-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5423ec154a14cd1b43222d048d37008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45ee86720a47f13b1546d76e5eed27a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d628f02d1c3830cb254e6da583a8aabb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfa07f40c3e9580108b3f36d491ff3dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27be51f575fdfef39b60144d5256f98a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_454d719690b5a71f9d4b1b594430791c |
| publicationDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2361338-T3 |
| titleOfInvention | PIRID-2-ONAS 3,5-USEFUL DISPOSED AS INHIBITORS OF THE TEC FAMILY OF TIROSINA KINASES NOT LINKED TO RECEIVER. |
| abstract | A compound of formula I: Formula I or a pharmaceutically acceptable salt thereof, wherein R2 is a 6-membered aryl ring or a 6-membered heteroaryl ring having 0-2 nitrogen atoms, said ring being optionally substituted. up to five JR2; each R3 and R4 is independently H, halogen or C1-4 aliphatic optionally substituted with 0-5 presence of halogen, OH, OCH3, OCF3, NO2, NH2, CN, NHCH3, SCH3, N (CH3) 2 or C1-2 aliphatic optionally substituted 0-5 times with F; V is or; in which V is optionally and independently substituted with 0-2 presence of halogen, C1-2 aliphatic, C1-2 haloaliphatic, OH, OCH3, OCF3 or CN. R is H or unsubstituted C1-6 aliphatic; R1 is independently H, halogen, CN, NO2 or C1-4 aliphatic optionally substituted with 0-4 presence of halogen, C1-2 aliphatic, CF3, OH, OCH3, OCF3, NO2, NH2, CN, NHCH3, SCH3 or N ( CH3) 2; Z is (T) n-Q; T is a C1-6 aliphatic chain, in which up to three methylene units of the chain are optionally and independently replaced by -NR5-, -O-, -S-, -SO-, -SO2-, -CS- or -CO-; T is optionally substituted with 0-3 JT; Q is a 3-8 membered, saturated, partially unsaturated or completely unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen or sulfur; or is a bicyclic ring system, 8-12 members, saturated, partially unsaturated or completely unsaturated having 0-5 heteroatoms independently selected from nitrogen, oxygen or sulfur; Q is optionally substituted with 0-5 JQ; n is 0 or 1; R5 is H, C1-6 aliphatic, C3-6 cycloaliphatic, phenyl, benzyl, CO (C1-4 aliphatic) or -SO2 (C1-6 aliphatic), each R5 being optionally substituted with 0-5 JR5 groups; each of JT and JR5 is independently H, C3-6 cycloaliphatic, C1-6 aliphatic, halogen, NO2, CN, -NH2, - NH (C1-4 aliphatic), -N (C1-4 aliphatic) 2, -OH , -O (C1-4 aliphatic), -CO2H, -CO2 (C1-4 aliphatic), -O (C1-4 haloaliphatic) or halo (C1-4 aliphatic); each of JR2 and JQ is independently halogen, -NO2, -CN, U, - (U) m- (C6-10 aryl), - (U) m- (5-12 membered heteroaryl), - (U) m- (3-12-membered heterocyclyl), - (U) m- (C3-10 cycloaliphatic), -OR0, -SR0, -N (R0) 2, - (C1-6 alkyl) -OR0, - (alkyl C1-6) -N (R0) 2, - (C1-6 alkyl) -SR0, -NR0C (O) R0, NR0C (S) R0, -NR0C (O) N (R0) 2, -NR0C (S) N (R0) 2, NR0CO2R0, - NR0NR0C (O) R0, -NR0NR0C (O) N (R0) 2, -NR0NR0CO2R0, -C (O) C (O) R0, -C (O) CH2C (O) R0 , -CO2R0, -C (O) R0, -C (S) R0, - C (O) N (R0) 2, -C (S) N (R0) 2, -OC (O) N (R0) 2 , -OC (O) R0, -C (O) N (OR0) R0, -C (NOR0) R0, -S (O) 2R0, -S (O) 3R0, -SO2N (R0) 2, - S ( O) R0, -NR0SO2N (R0) 2, -NR0SO2R0, -N (OR0) R0, -C (= NH) -N (R0) 2, -P (O) 2R0, -PO (R0) 2, -OPO (R0) 2, = O, = S, = NHHR0, = NN (R0) 2, = NNHC (O) R0, = NNHCO2 (C1-6 alkyl), = NNHSO2 (C1-6 alkyl), = NOH or = NR0; each JR2 and JQ being optional and independently substituted with 0-5 RX; U is a C1-10 alkylidene chain, in which up to three methylene units of the chain are independently replaced by -NR0, -O-, -S-, -SO-, SO2- or -CO-; m is 0 or 1 each Rx is independently halogen, NO2, CN, NH2, NH (C1-4 aliphatic), N (C1-4 aliphatic) 2, OH, O (C1-4 aliphatic), O (C1-4 haloaliphatic ), CO (C1-4 aliphatic), CO2H, CO2 (C1-4 aliphatic), C1-6 aliphatic, C1-4 haloaliphatic, phenyl, -O (Ph), 5-6 membered heteroaryl, C3-8 cycloaliphatic, 5-8 membered heterocyclyl, -C 1-6 aliphatic (Ph), -C 1-6 alkyl- (5-6 membered heteroaryl), -C 1-6 alkyl- (C 3-8 cycloaliphatic), -C 1-8 alkyl - (5-8 membered heterocyclyl) or a C1-10 alkylidene chain in which up to 2 methylene units of the chain are optionally substituted by O, N or S; each Rx being optional and independently substituted with 0-5 J0; each R0 is independently H, C1-6 aliphatic, C1-4 haloaliphatic, CO (C1-4 aliphatic), CO2 (C1-4 aliphatic), -SO2 (C1-4 aliphatic), -SO2 (phenyl), phenyl, heteroaryl 5-6 membered, 5-6 membered heterocyclyl, C3-8 cycloaliphatic, C1-6 aliphatic (Ph), C1-6 alkyl- (5-6 membered heteroaryl), C1-6 alkyl 5-8 membered heterocyclyl), -C 1-6 alkyl- (C 3-8 cycloaliphatic); or a C1-10 alkylidene chain in which up to 2 methylene units of the chain are optionally replaced by O, N or S; said R0 being optionally substituted with 0-5 J0; or two R0, on the same substituent or on different substituents, taken together with the atom or atoms to which each R0 is attached, form a 3-8 membered monocyclic or bicyclic ring, saturated, partially unsaturated or completely unsaturated, which it has 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; said ring being optionally and independently substituted with 0-4 presence of halogen, NO2, CN, C1-4 aliphatic, NH2, NH (C1-4 aliphatic), N (C1-4 aliphatic) 2, OH, O (C1- aliphatic 4), CO2H, CO2 (C1-4 aliphatic), O (C1-4 haloaliphatic) or C1-4 haloaliphatic, in which each of the C1-4 aliphatic groups of R0 is unsubstituted; each J0 is independently halogen, NO2, CN, C1-4 aliphatic, -NH2, -NH (C1-4 aliphatic), -N (C1-4 aliphatic) 2, -OH, - O (C1-4 aliphatic), - CO2H, -CO2 (C1-4 aliphatic), -O (C1-4 haloaliphatic) or halo (C1-4 aliphatic), in which each C1-4 aliphatic group is unsubstituted. |
| priorityDate | 2005-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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