| abstract |
An isolated specific binding member for human IL-13, which comprises an antibody antigen binding site that is comprised of a human antibody VH domain and a human antibody VL domain and which comprises a CDR set HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, in which the VH domain comprises HCDR1, HCDR2 and HCDR3 and the VL domain comprises LCDR1, LCDR2 and LCDR3, in which the CDR set consists of a set of CDRs selected from the group consisting of : the CDR set of BAK278D6, defined in which HCDR1 has the amino acid sequence of SEQ ID NO: 1, HCDR2 has the amino acid sequence of SEQ ID NO: 2, HCDR3 has the amino acid sequence of SEQ ID NO: 3 , LCDR1 has the amino acid sequence of SEQ ID NO: 4, LCDR2 has the amino acid sequence of SEQ ID NO: 5 and LCDR3 has the amino acid sequence of SEQ ID NO: 6; and the CDR set of BAK502G9, defined in which HCDR1 has the amino acid sequence of SEQ ID NO: 7, HCDR2 has the amino acid sequence of SEQ ID NO: 8, HCDR3 has the amino acid sequence of SEQ ID NO: 9 , LCDR1 has the amino acid sequence of SEQ ID NO: 10, LCDR2 has the amino acid sequence of SEQ ID NO: 11 and LCDR3 has the amino acid sequence of SEQ ID NO: 12; wherein the specific binding member binds to human IL-13 and IL-13 of rhesus or cynomolgus. |