http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2359653-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4245 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2007-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6380a621eeb31e882a9f78badc450a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f16533fa4af1e4eaeff61cf2930b001b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_941a94f199317c472f4a9f512938f5ee |
| publicationDate | 2011-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2359653-T3 |
| titleOfInvention | BENCIMIDAZOLES AND ITS USE FOR THE TREATMENT OF DIABETES. |
| abstract | A compound of formula (I) or a salt thereof, wherein: R1 is selected from phenyl, cyclopentyl, cyclohexyl and HET-1, wherein R1 is optionally substituted with or: i) a substituent selected from group a) and optionally a substituent selected from either group b) or group c); or ii) 1 or 2 substituents independently selected from group b) and optionally a substituent selected from group c); or iii) up to 4 substituents independently selected from group c); wherein groups a) to c) are as follows: group a) nitro, -C (O) nR20, a mimic carboxylic acid or one of its bioisterosters, -NR21R22, -C (O) NR21R22, -OC ( O) NR21R22, -NR21C (O) nR20, -NR20CONR21R22, -S (O) 2NR21R22 or NR21S (O) 2R22 where R20, R21 and R22 are independently selected from hydrogen and alkyl (1-6C) or R21 and R22 together with the nitrogen atom to which they are attached form an optionally substituted ring having 3 to 10 atoms, optionally containing additional heteroatoms such as S (O) m, oxygen and nitrogen; group b) R1 is optionally substituted with 1 or 2 substituents independently selected from haloalkyl (1-6C), cyano, alkyl (1-6C), hydroxy, alkoxy (1-6C), benzyloxy, -SOm alkyl (1-6C) and -OSO2alkyl (1-6C); group c) halo; and when R1 is substituted with two alkoxy groups (1-6C), these can be joined to form a 5 or 6 membered ring fused to R1; n is (independently in each case) 1 or 2; m is (independently in each case) 0, 1 or 2; L1 is a direct bond or in a binder selected from -O-, -OCH2-, -CH2O-, -S (O) m-, S (O) mCH2-, -CH2S (O) m- and - (CR7R8) 1-2-; R2 is selected from cycloalkyl (3-6C), bicycloalkyl (5-12C), phenyl, HET-2 and alkyl (2-6C); wherein R2 is optionally substituted with -L2-R3; L2 is a direct bond or is a binder selected from - (CR4R5) 1-2-, -O- (CR4R5) 1-2- and - CH2 (CR4R5) 1-2- (where for each value of L2, the group CR4R5 is directly linked to R3); each R4 is independently selected from hydrogen, hydroxy, alkoxy (1-3C), alkyl (1-4C), hydroxyalkyl (1-3C) and alkoxy (1-2C) alkyl (1-2C); with the proviso that when L2 is -O- (CR4R5) 1-2- then R4 in the carbon atom attached directly to the oxygen atom is not hydroxy or alkoxy (1-3C); each R5 is independently selected from hydrogen and methyl; R3 is selected from hydroxy, carboxy, (1-6C) alkoxycarbonyl, and a mimic or bioisteric carboxylic acid; R6 is selected from hydrogen, fluoro, chloro, hydroxy, methoxy, haloalkyl (1-2C), methyl, ethyl, cyano and methylsulfonyl; each R7 is independently selected from hydrogen, (C1-4) alkyl and (C1-4) alkoxy; each R8 is independently selected from hydrogen and methyl; HET-1 is a 5 or 6-membered heteroaryl ring containing 1 or 2 heteroatoms in the ring independently selected from O, N and S (with the proviso that there are no O-O, S-S or O-S bonds within the ring); HET-2 is a saturated, partially or totally unsaturated, 4, 5 or 6-membered heterocyclyl ring containing 1, 2 or 3 ring heteroatoms independently selected from O, N and S (with the proviso that there are no OO bonds , SS or OS within the ring), where a carbon atom of the ring can be oxidized to C (O) and / or a sulfur atom of the ring can be oxidized to S (O) or S (O) 2. |
| priorityDate | 2006-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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