http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2359415-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-663 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-663 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 |
| filingDate | 2005-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_321feb4bd0ae2bfb4dd29a312fe99eba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1840d1af733c6fd7323d9d94ffdb6de4 |
| publicationDate | 2011-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2359415-T3 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF IBANDRONATE. |
| abstract | A process for the preparation of the monohydrate of the monosodium salt of 3- (N-methyl-Npentyl) amino-1-hydroxypropan-1,1-diphosphonic acid whose process comprises: (a) condensation of N-pentylamine with benzaldehyde to produce the N-benzylidene-N-pentylamine of formula II (b) transformation of N-benzylidene-N-pentylamine into N-methyl-N-pentylamine with a methylating agent (c) conversion of N-methyl-N-pentylamine with methyl N-methyl-N-pentyl-β-alanine methyl ester acrylate of the formula III (d) N-methyl-N-pentyl-β-alanine methyl ester hydrolysis and subsequent hydrohalogenide formation to produce the compound of formula IV wherein X is a halogen, (e) bisphosphorylation of the compound of formula IV by means of phosphoryl chloride and phosphorous acid and after addition of sodium hydroxide formation of the monosodium salt monohydrate. |
| priorityDate | 2004-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.