| abstract |
The present invention describes chimeric vaccine antigens against the virus that causes Classical Swine Plague disease (VPPC). These vaccine antigens are based on viral subunits that are coupled to immune-stimulating protein molecules, both cellular and humoral. The chimeric antigens can be produced in expression systems that guarantee a correct three-dimensional folding of the chimeric molecules that form the basis of the present invention. Vaccine compositions containing such chimeric antigens induce a potent and early immune response in vaccinated pigs, giving it full protection against VPPC. In addition, the resulting vaccine compositions prevent viral transmission of mothers to their offspring. The chimeric antigens, as well as the resulting vaccine compositions are applicable to the sphere of animal health, such as vaccines for preventive use in pigs. |