http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2357391-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb66d9373d09efad73c142762f6dfb00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33 |
| filingDate | 2005-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a45ca92e70348a165d294034e4f36bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_054120169f710f297139d20214d13407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f9b12e25ac62ebec9eb31190b5ce55f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_860d5fc5613e4b62a369784c03a5863b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc166182860fb5e62398d9a63a76400b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_020bfc06092863b9723cf1e512a1284d |
| publicationDate | 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2357391-T3 |
| titleOfInvention | BENZOFENONE ALKYNIC DERIVATIVES AS NON-NUCLEOSIDE INVERTERS OF INVERSE TRANSCRIPT. |
| abstract | A compound of formula (I): where R 1 and R 2 are independently selected from H, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl ), -O-C 1-4 alkyl, -COO-C 1-4 alkyl, -CONH2, -CONH-C 1-4 alkyl and -CON (C 1-4 alkyl) 2; and said (C1-4) alkyl is optionally substituted with one, two or three halogen substituents; and said -O-C 1-4 alkyl is optionally substituted with -COO-C 1-4 alkyl or with one, two or three halogen substituents; with the proviso that if R 1 is H, R 2 cannot be H; R 3 is chosen between H and halogen; R 4 is chosen from (C1-4) alkyl, halogen and nitro; Q is chosen between N and CR 5, where R 5 is chosen between H and halogen; R 6 is chosen between H and halogen; R 7 is chosen from -C 1-6 alkyl-R 8 and a 5-membered saturated heterocycle bearing a heteroatom chosen from N, O and S; wherein said heterocycle is optionally substituted with one, two or three substituents independently selected from (C1-6) alkyl and oxo; and wherein the (C1-6) alkyl portion of said -C 1-6 alkyl-R 8 is optionally monosubstituted with -OH and optionally substituted with one to six halogen substituents; and where R 8 is chosen from: a) -OH, -COOH, -CONHSO2R 9, -C (= O) NHOH, -OC (= O) NH2 or -NH2, where R 9 is (C1-6) alkyl or cycloalkyl (C3-7); b) -O-(C2-6) alkyl -OH, -NH-(C2-6) alkyl -OH, -O- (C1-6) alkyl -R 81 or -NH-C1-6 alkyl -R 81, where R 81 is chosen from Het, -CONHSO2R 9 and -COOH; where R 9 is as defined above; c) -NHC (= O) -R 82, where R 82 is selected from (C1-6) alkyl, (C2-6) alkenyl, (C3-7) cycloalkyl, phenyl, -NH2, -NH-alkyl (C1-6), -N ((C1-6) alkyl) 2 and Het; and each of said alkyl (C1-6), alkenyl (C2-6), cycloalkyl (C3-7), phenyl and Het is optionally substituted with one or more substituents independently selected from -OH, -COOH, -CONHSO2R 9, -SO2NH2, -NH2, -NH-C1-6 alkyl, -N (C1-6 alkyl) 2, Het and -NH-Het; where R 9 is as defined above; wherein the (C1-6) alkyl portions of said -NH-(C1-6) alkyl and -N ((C1-6) alkyl) 2 are independently and optionally substituted with -O-(C1-6) alkyl, -CONHSO2R 9 or -COOH; where R 9 is as defined above; and wherein said Het and the Het fragment of said -NH-Het are optionally substituted with -COOH or -CONHSO2R 9; where R 9 is as defined above; and d) -C (= O) N (R 83) R 84, where R 83 is chosen from H and alkyl (C1-6); and R 84 is chosen from (C1-6) alkyl and Het; and each of said (C1-6) alkyl and Het is optionally substituted with one or more substituents independently selected from -OH, -COOH, -CONHSO2R 9 and -SO3H; where R 9 is as defined above; or R 83 and R 84 are connected together with the nitrogen atom to which they are attached, forming a single or 5-membered ring heterocycle, which can be saturated, unsaturated or aromatic and optionally contain one to three additional heteroatoms independently chosen from N, O and S; and said heterocycle is optionally substituted with -COOH or -CONHSO2R 9; where R 9 is as defined above; where Het is a 4, 5 or 6 member heterocycle or a 9 or 10 member heterocycle, each of which can be saturated, unsaturated or aromatic and contain one to four heteroatoms independently selected from N, O and S, where each of said heteroatoms N can be, independently and where possible, in an oxidation state that further allows their binding to an oxygen atom to form an N-oxide group, and where each of said heteroatoms S can be, independently and where possible, in an oxidation state that also allows their binding to one or two oxygen atoms to form the SO or SO2 groups; or a salt or ester thereof. |
| priorityDate | 2004-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 315.