http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2356886-T3

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filingDate 1999-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2011-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_353a619b8cd6b93bb13cf6826cf1c38b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec94648f6854b018f40189b09cf1464e
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publicationDate 2011-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2356886-T3
titleOfInvention NITROGEN HETEROCYCLIC COMPOUNDS.
abstract Nitrogen-containing heterocyclic compound, represented by the formula in which: W represents 1,4-piperazindiyl, in which the carbon atoms in the ring may be substituted with between 1 and 4 alkyl groups, which are the same or different; R 1 represents a hydrogen atom, and R 2 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaryl group, or a substituted or unsubstituted heteroarylalkyl group; V represents an oxygen atom or a sulfur atom; one). D 1 and D 2 combine to represent a nitrogen atom; D 3 represents CR C, in which RC represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, or a halogen atom, and in which the substituents of the substituted alkyl group and of the substituted alicyclic alkyl group are the same or different and include between 1 and 3 substituents, selected from a nitro group, a cyano group, a hydroxyl group, an oxo group, and a halogen atom; and D 4 represents N-R 2B ', wherein R 2B' represents a hydrogen atom or an unsubstituted alicyclic alkyl group, 2). D 1, D 2 and D 4 each independently represent C-R C (in which R C has the same meaning as defined above); and D 3 represents a nitrogen atom, in which the substituents of the substituted aryl group, of the substituted aralkyl group, of the substituted heteroaryl group, and of the substituted heteroarylalkyl group, are the same or different, and are 1 to 3 substituents, selected from a nitro group, a cyano group, a hydroxyl group, a halogen atom, a methylenedioxy group, (OCH2CH2) nO (in which n is an integer from 1 to 6), a trimethylene group, a trifluoromethyl group, a difluoromethoxy group , a trifluoromethoxy group, an azido group, a thiocyanate group, an alkyl group substituted with R 19 (in which R 19 represents a hydroxyl group, an oxo group, or NR 20 R 21 (in which R 20 and R 21 are the same or different, and each represents a hydrogen atom, an alkyl group, an alicyclic alkyl group, an alicyclic heterocyclic group, an alkenyl group, an alkynyl group, an aryl group, an aralkyl group, a heteroaryl group, or a group heteroarylalkyl, or R 20 and R 21 are combined to represent a nitrogen-containing heterocyclic group)) or an unsubstituted alkyl group, an alicyclic alkyl group substituted with R 16 (wherein R 16 represents an alkyl group, a nitro group, a cyano group, a hydroxyl group , a halogen atom, or NR 17 R 18 (wherein R 17 and R 18 are the same or different, and each represent a hydrogen atom, an alkyl group, an alicyclic alkyl group, an alicyclic heterocyclic group, a group alkenyl, an alkynyl group, an aryl group, an aralkyl group, a heteroaryl group, or a heteroarylalkyl group, or R 17 and R 18 are combined to represent a heterocyclic group containing nitrogen)) or an unsubstituted alicyclic alkyl group, a alicyclic heterocyclic group, an alkenyl group, an alkynyl group, an aryl group, an aralkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a formyl group, G 1 -J 1 -R 15 {in which G 1 represents a link simple, an oxygen atom, or a sulfur atom; J 1 represents CO, CS, or SO2; and R 15 represents an alkyl group, an alicyclic alkyl group, an alicyclic heterocyclic group, an alkenyl group, an alkynyl group, an aryl group substituted with R 16 (wherein R 16 has a meaning as defined above) or a group unsubstituted aryl, an aralkyl group, a heteroaryl group, a heteroarylalkyl group, an alkoxy group, a trifluoromethyl group, a trifluoromethoxy group, an alicyclic alkoxy group, a hydroxyl group substituted with an O-alicyclic hetero ring, an alkenyloxy group, a group alkynyloxy, an aryloxy group substituted with R 16 (where R 16 has the same meaning as defined above) or an unsubstituted aryloxy group, an aralkyloxy group, a heteroaryloxy group, a heteroarylalkoxy group, an amino group, an alkylamino group , an alicyclic alkylamino group, an amino group substituted with an N-alicyclic hetero ring substituted with R 19 (wherein R 19 represents a hydroxyl group, an oxo group, or NR 20 R 21 (e where R 20 and R 21 are the same or different, and each represents a hydrogen atom, an alkyl group, an alicyclic alkyl group, an alicyclic heterocyclic group, an alkenyl group, an alkynyl group, an aryl group, a group aralkyl, a heteroaryl group, or a heteroarylalkyl group, or R 20 and R 21 are combined to represent a nitrogen-containing heterocyclic group)) or an amino group substituted with an unsubstituted N-alicyclic hetero ring, an alkenylamino group, an alkylamino group , an arylamino group substituted with R 16 (in which R 16 has the same meaning as defined above) or an unsubstituted arylamino group, an aralkylamino group, a heteroarylamino group, or a heteroarylalkylamino group}, NR 22 R 23 (in which R 22 and R 23 are the same or different, and each represents a hydrogen atom, an alkyl group, an alicyclic alkyl group, an alicyclic heterocyclic group, an alkenyl group, an alkynyl group, a group a R 16 substituted ryl (in which R 16 has the same meaning as defined above) or an unsubstituted aryl group, an aralkyl group, a heteroaryl group, a heteroarylalkyl group, an alkanoyl group, an alicyclic alkanoyl group, a group alicyclic heteroanular carbonyl, an alkenoyl group, an alkynyl group, an aroyl group substituted with R 16 (in which R 16 has the same meaning as defined above) or an unsubstituted aroyl group, an aralkylcarbonyl group, a heteroarylcarbonyl group, a heteroarylalkylcarbonyl group, an alkoxycarbonyl group, an alicyclic alkoxycarbonyl group, a hydroxycarbonyl group substituted with an O-alicyclic hetero-ring, an alkenyloxycarbonyl group, an alkynyloxycarbonyl group, an aryloxycarbonyl group substituted with R 16 (where R 16 has the same meaning as defined above) or an unsubstituted aryloxycarbonyl group, an aralkyloxycarbonyl group, a heteroaryloxycarbon group ilo, a heteroarylalkoxycarbonyl group, an alkylsulfonyl group, an alicyclic alkylsulfonyl group, an alicyclic heteroanular sulfonyl group, an alkenylsulfonyl group, an alkylsulfonyl group, an R 16 substituted arylsulfonyl group (wherein R 16 has the same meaning as defined above) ) or an unsubstituted arylsulfonyl group, an aralkylsulfonyl group, a heteroarylsulfonyl group, a heteroarylalkyl sulfonyl group, or -CQ F NR 17A R 18A (wherein QF represents an oxygen atom or a sulfur atom; and R 17A and R 18A have the same meaning as R 17 and R 18 defined above), or R 22 and R 23 combine to represent a nitrogen-containing heterocyclic group), an alkoxy group, an alicyclic alkoxy group, a hydroxyl group substituted with an O-alicyclic hetero ring, an alkenyloxy group, an alkynyloxy group, an aryloxy group substituted with R 18 (wherein R 18 has the same meaning as defined above) or an unsubstituted aryloxy group, an aralkyloxy group, a heteroaryloxy group, a heteroarylalkoxy group, a sulfo group, a trifluoromethylthio group, an alkylthio group, an alicyclic alkylthio group, an alicyclic heteroannular thio group, an alkenylthio group, an alkynylthio group, an arylthio group substituted with R 16 (in which R 16 has the same meaning as defined above) or an unsubstituted arylthio group, an aralkylthio group, a heteroarylthio group, a heteroarylalkylthio group, a trifluoromethylsulfinyl group, an alkyl group sulfinyl, an alicyclic alkylsulfinyl group, an alicyclic heteroannular sulfinyl group, an alkenylsulfinyl group, an alkylsulfinyl group, an R 16 substituted arylsulfinyl group (wherein R 16 has the same meaning as defined above) or an unsubstituted arylsulfinyl group, an aralkylsulfinyl group, a heteroarylsulfinyl group, a heteroarylalkylsulfinyl group, an arylazo group substituted with R 16 (in which R 16 has the same meaning as defined above) or an unsubstituted arylazo group, or a heteroarylazo group, or a pharmaceutically salt acceptable of them.
priorityDate 1998-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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